Osteoarthritis (OA) is the most common form of arthritis. Meloxicam are one NSAIDs commonly used that have many side effects. Areca nut (Areca catechu L), which contains flavonoids, can provide anti-inflammatory This study aimed to determine potential effect ethyl acetate fraction from ripe areca in OA rat model. Twenty five adults, male Rattus novergicus strain Wistar were induced with Monosod...

Oral submucous fibrosis (OSF) is a chronic inflammatory disease characterized by the accumulation of excess collagen, and areca nut chewing has been proposed as a significant etiological factor for disease manifestation. However, the underlying molecular mechanisms regarding areca nut chewing-induced OSF are only partially understood. Herein, we reported that arecoline markedly induced morpholo...

A betel nut (also called betel quid) usually consists of three major ingredients: a raw areca nut, slaked lime, and Piper betle inflorescence. The size of a betel nut is usually about 3 cm × 3 cm × 2 cm (Figure 1). The acidity of a raw areca nut can cause stomach problems after repeated intake. With high alkalinity, the slaked lime can neutralize this acidity. Arecoline (the primary alkaloid in...

Areca catechu L. nut, a well-known toxic traditional herbal medicine, has been widely used to treat various diseases in China and many other Asian countries for centuries. However, to date the in vivo absorption and metabolism of its multiple bioactive or toxic components still remain unclear. In this study, liquid chromatography coupled with tandem mass spectrometry was used to analyze the maj...

oral submucous fibrosis (osmf) is a potentially malignant oral condition effectively linked to the causative habit of chewing areca nut. since its first description in the 1950s, numerous epidemiological, biochemical, histological, and genetic studies have been reported. while most studies point out to the cause and effect of areca nut, co-additive factors are also implicated in the progression...

The South Asian community is the largest and one of the fastest growing minority groups in Canada, according to the 2006 census. These immigrants bring to Canada talents and skills that can promote Canada's economy and cultural diversity, but they also bring lifestyle habits that may lead to serious health issues. Chewing areca nut and betel quid (paan, with and without tobacco) is a known risk...

This article describes a male patient who presented with trismus due to submucous fibrosis and how in course of time it turned malignant into oral squammous cell carcinoma. Oral submucous fibrosis (OSF) is a chronic, complex, irreversible, highly potent pre-cancerous condition characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues (lamina prop...