Adaptation of Saccharomyces cerevisiae cells to arsenic stress is mediated through the activation of arsenic detoxification machinery by the Yap8 transcription factor. Yap8 is targeted by the ubiquitin proteasome system for degradation under physiological conditions, yet it escapes proteolysis in arsenic-injured cells by amechanism that remains to be elucidated. Here, we show that Ufd2, an E4-U...

Salmon is a kind of fish which has good nutrition for human but it can be contaminated by heavy metal such as arsenic. In risk assessment , the provisional tolerable weekly intake (PTWI) for inorganic arsenic is 15 μg/kg b.w./week and the organic forms of arsenic present in sea foods need different consideration from the inorganic arsenic in water. There are no reports of toxicity in man or ani...

In this study, the binding of amlodipine (a Ca ++ channel Blocker) and arsenic (metalloid) to bovine serum albumin (BSA) was studied by equilibrium dialysis(ED) method in order to have an insight into their binding chemistry to BSA. Free amlodipine concentration was increased due to addition of arsenic which reduced the binding of the compounds to BSA. However, the free fraction was not increa...

While arsenic compounds are known as environmental toxicants (especially in drinking water) and as carcinogens, some arsenic compounds, like arsenic trioxide (As2O3), are clinically used in humans to treat some forms of cancer (e.g. leukemia). Although arsenic compounds have been studied intensively, their interactions with living cells are still not fully elucidated. We have previously propose...

24 25 26 UN CO RR EC TE D PR Abstract. Selenium (Se) and arsenic are next-door neighbors on the periodic table and have similar chemical properties as metalloids. Arsenic antagonizes selenium toxicity in a number of organisms. Inorganic arsenic in drinking water is a human carcinogen while selenium compounds are anticarcinogenic in animals and humans. Our previous work showed that arsenite enha...

1. We have shown that the type of renal lesion produced by compounds of arsenic varies widely: while some arsenicals produce changes in which vascular injury predominates, others produce an equally dominant tubular injury. 2. In either of these groups the character and degree of the vascular or tubular injury produced by different compounds shows further variation, such that the lesions of diff...