Pelvic arteriovenous malformations (AVMs) are uncommon entities that can present with symptoms resulting from compression of adjacent structures, ischemia due to 'steal phenomenon' or, rarely, heart failure. We present a case of heart failure in a patient who presented to our facilities for heart transplant and a prior diagnosis of idiopathic dilated cardiomyopathy; further evaluation revealed ...

BACKGROUND The hemodynamic evaluation of cerebral arteriovenous malformations (AVMs) using DSA has not been validated against true flow measurements. OBJECTIVE To validate AVM hemodynamics assessed by DSA using quantitative magnetic resonance angiography (QMRA). MATERIALS AND METHODS Patients seen at our institution between 2007 and 2016 with a supratentorial AVM and DSA and QMRA obtained b...

BACKGROUND AND PURPOSE The goal of this study was to analyze the association of hemorrhagic presentation with infratentorial brain arteriovenous malformations (AVMs). METHODS The 623 consecutive, prospectively enrolled patients from the Columbia AVM Databank were analyzed in a cross-sectional study. Clinical presentation (diagnostic event) was categorized as intracranial hemorrhage or nonhemo...

Arteriovenous malformation (AVM) is an abnormal connection between arteries and veins, bypassing the capillary system. In most cases, the disorder may be asymptomatic. The objective of endovascular AVM treatment is set individually for each case upon consultations with a neurosurgeon and a neurologist. The endpoint of the treatment should consist in prevention of AVM bleeding in a management pr...

BACKGROUND AND PURPOSE CM-AVM is a recently recognized autosomal dominant disorder associated with mutations in RASA1. Arteriovenous lesions have been reported in the brain, limbs, and the face in 18.5% of patients. We report a novel association between RASA1 mutations and spinal arteriovenous anomalies. MATERIALS AND METHODS In a collaborative study, 5 index patients (2 females, 3 males) wit...

We report a 73-year-old woman with de novo arteriovenous malformations (AVMs) that developed in the ipsilateral parietal lobe after craniotomy and aneurysm clipping. While intracerebral AVMs are considered to be congenital lesions, there have been several reported cases of acquired AVM arising after ischemic or traumatic episodes. We summarize previously reported cases of such acquired 'de novo...

Spinal myoclonus with arteriovenous malformations (AVMs) of the spinal cord after intravenous administration of contrast material is extremely rare. Only one case of spinal myoclonus after intravenous infusion of contrast medium for computed tomography (CT) was found in our literature review [1]. We report a second case of spinal myoclonus and symptoms of a transverse spinal lesion consequent t...

SUMMARY The purpose of this study was to evaluate the efficacy of a newly designed circular ring compression device that allows safe and effective glue injection during preoperative embolization of high-flow superficial craniofacial arteriovenous malformations (AVMs). The device was used in 4 cases of craniofacial AVM with multiple feeding arteries and draining veins. It provided a safe glue in...

Arteriovenous malformations (AVMs) are fragile direct connections between arteries and veins that arise during times of active angiogenesis. To understand the etiology of AVMs and the role of blood flow in their development, we analyzed AVM development in zebrafish embryos harboring a mutation in activin receptor-like kinase I (alk1), which encodes a TGFβ family type I receptor implicated in th...

The RASA1 gene encodes p120RASGAP, a multidomain cytoplasmic protein that acts as a negative regulator of the RAS signalling pathway. Heterozygous loss-of-function RASA1 mutations were identified in patients with Parkes Weber syndrome and multifocal capillary malformations. This syndrome is characterised by a capillary blush on an extremity, arteriovenous microfistulas, and bony and soft tissue...