Protein expression monitoring can be a good tool to determine disease onset and progression, and is also used in drug discovery and investigational science (1–4). However, commonly used assays lack the sensitivity and specificity required for the detection of low-abundance proteins (5,6). Several signal amplification technologies have been designed and applied to protein detection assays, inclu...

Proof. Proceed by contradiction. Suppose that f has more than one root in (0,∞). Let r1 and r2, with r1 < r2, be two consecutive such roots (note that we can always find two consecutive roots r1 and r2 because f (r) > 0 for any root r). From the hypothesis, we have f (r1) > 0 and f (r2) > 0. Since f ′ is continuous at r1, there exists an 0 < 2 < (r2− r1) such that f (x) > 0 in the interval (r1,...

Non-invasive measurement of body composition provides advantages in growth studies compared to conventional techniques. The same individual can be measured several times, the measurement is faster, and the number of pigs required as well as the random effect of animal are reduced. The aim of the present study was to determine the composition of the half carcass and of the ham/shank region by a ...

Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, acting through the TNF-R1 and TNF-R2 receptors. The two receptors have been proposed to mediate distinct TNF-alpha effects in the CNS, TNF-R1 contributing to neuronal damage and TNF-R2 being neuroprotective. Whether TNF-alpha and its receptors play any role for neurogenesis in the adult brain is unclear. Here we used mouse m...

i=1 H(ri); (5) HΨ(r1, r2, · · · ) = EΨ(r1, r2, · · · ). (6) (Note: For simplicity, unless necessary, we often write r as r.) Since there is no interaction between particles, the Schrodinger equation is separable. Assume Ψ(r1, r2, · · · , rN ) = φ(r1)φ(r2) · · ·φ(rN ), (7) then Hφαi(ri) = εαiφαi(ri), i = 1, 2, · · ·N. (8) Manybody eigenstate is a product of 1-particle states, Ψα1,α2,···(r1, r2, ...

PURPOSE The cell surface receptors tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and TRAIL-R2 transmit apoptotic signals, and agents that activate these receptors are in clinical development. We sought to determine the expression and prognostic value of TRAIL-R1 and TRAIL-R2 in early-stage breast cancer. EXPERIMENTAL DESIGN Tissue microarrays containing specime...