A series of structurally related 2,4-dioxopyrimidine-1-carboxamide derivatives as highly potent inhibitors against acid ceramidase were subjected to hologram quantitative structure-activity relationship (HQSAR) analysis. A training set containing 24 compounds served to establish the HQSAR model. The best HQSAR model was generated using atoms, bond, connectivity, donor and acceptor as fragment d...

27 血管内コイル塞栓術を受けた脳動脈瘤性くも膜下出血患者における clazosentan の無作為試験 Randomized Trial of Clazosentan in Patients With Aneurysmal Subarachnoid HemorrhageUndergoing Endovascular Coiling R. Loch Macdonald, MD, PhD1; Randall T. Higashida, MD2; Emanuela Keller, MD3; Stephan A. Mayer, MD4;Andy Molyneux,MD5; Andreas Raabe, MD6; Peter Vajkoczy, MD7; Isabel Wanke, MD8,9; Doris Bach, MSc10;Aline Frey...

Vasospasm following traumatic brain injury (TBI) may dramatically affect the neurological and functional recovery of a vulnerable patient population. While the reported incidence of traumatic vasospasm ranges from 19%-68%, the true incidence remains unknown due to variability in protocols for its detection. Only 3.9%-16.6% of patients exhibit clinical deficits. Compared to vasospasm resulting f...

Hypocalcemia and hyperphosphatemia caused by parathyroid hormone (PTH)-resistance are the only discernible abnormalities in pseudohypoparathyroidism type Ib (PHP-Ib). Because mutations in the PTH/PTH-related peptide receptor, a plausible candidate gene, had been excluded previously, we conducted a genome-wide search with four PHP-Ib kindreds and established linkage to a small telomeric region o...

Chemical modification of naturally occurring polysaccharide, guaran has been made by incorporating 5aminosalicylic hydroxamate moiety to improve its selectivity and capacity for heavy metal ions. 5Amino salicylic acid hydroxamate derivative of guaran (ASAH-G) was synthesized, characterized and its adsorption behavior with Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), U(VI), W(VI), Cr(VI) and ...

Stray voltage (usually <10 V) can occur in farms. However, very little information is available related to sheep. In addition, little work has been carried out on the effects of the contextual conditions under which the animals are submitted to stray voltage. The aims of this study were (i) to determine the threshold voltage at which lambs start to express avoidance behaviour and (ii) to test i...

Generally, testing any application should be both effective, in that the testing covers a wide range of functionality, and efficient, in that the testing process is as short as possible. As dynamic web applications increase in size, the developer’s test input size also increases; therefore, testing by hand is neither effective nor efficient. The developer must manually check all inputs for all ...

We present a new archeointensity database application that stores data of the Earth’s magnetic field intensity for the last 7000 years. Our application allows users to query and rank data according to selectable criteria. It is also possible to plot the data as archeointensity curves. Users can access the database using any Web browser and see the results of their queries immediately on the scr...

The skin protects the human body by providing barrier function. Interleukin (IL)-33 is a tissue-derived cytokine, mainly expressed epithelial and endothelial cells, known to activate Th2 lymphocytes, mast ILC2, eosinophils. We aimed study role of IL-33 in Wild-type (WT), knockout (IL-33KO) mice were tape stripped, trans-epidermal water loss (TEWL) was monitored. Skin samples corrected, hematoxy...