background: absent in melanoma 2 (aim2) is an intracellular microbial dsdna sensor which plays an important role in production of proinflammatory cytokines through apoptosis associated speck-like protein containing a caspase activation and recruitment domain (asc) and caspase-1. micro-rnas (mirnas) play important roles in regulation of immune related genes. however, there is little information ...

We verified the prevalence of human papillomavirus (HPV) E6/E7 protein mRNA expression in patients with low-grade squamous intraepithelial lesions (LSILs) and negative cervicovaginal cytology. To investigate the relationship between mRNA expression and viral infection type, we assessed genotyping in single infections. Samples from 825 women were submitted to the E6/E7 survey. We noticed a large...

sudarshan churna (sc) is very potent ayurvedic medicine ; composed of 42 medicinal plants, which is used traditionally in treatment of malaria, viral fever, and bacterial infection. the present study was designated to evaluate the antimicrobial activity of aqueous extract of sudarshan churna (asc) using the paper disc diffusion method. the asc was found active against the gram-negative bacteria...

ABSTRACT
 Objective: The aim of our study is to compare the clinical data and colposcopy- directed biopsy (CDB) results atypical squamous cell undetermined significance (ASC-US) low-grade intraepithelial lesion (LSIL) cytology among high risk human papilloma virus (hrHPV) positive women.
 Materials Methods: A total 359 hrHPV-positive patients with ASC-US LSIL cytology, between 20-67 y...

Inflammasome, an intracellular inflammatory machinery, has been reported to be involved in a variety of chronic degenerative diseases such as atherosclerosis, autoinflammatory diseases and Alzheimer's disease. The present study hypothesized that the formation and activation of inflammasomes associated with apoptosis associated speck-like protein (ASC) are an important initiating mechanism resul...

Many people on the autism spectrum report having difficulties or differences in sensory perception. For example, in Temple Grandin’s famous book “Thinking In Pictures” she describes her sensory experiences the following: “From as far back as I can remember, I always hated to be hugged. I wanted to experience the good feeling of being hugged, but it was just too overwhelming. It was like a great...

The aim of this study was to analyze the correlation between the first diagnosis of high-grade Vaginal Intraepithelial Neoplasia (HG-VaIN: VaIN 2-VaIN 3) and the cytological abnormalities on the referral pap smear.All the women with histological diagnosis of HG-VaIN consecutively referred to the Gynecological Oncology Unit of the Aviano National Cancer Institute (Aviano, Italy) from January 199...

On the basis of its absence in transport-deficient phenotypes, Young and his associates have discovered in the erythrocytes of sheep and horses a type of Na+-independent transport system that resembles Na+-dependent ASC somewhat in its amino-acid selectivity. These authors have stressed this similarity and accordingly suggested that System ASC might have lost its Na+-dependence in the course of...

PURPOSE to identify valid guidelines for the approach of women with cytopathological diagnosis of undetermined significance atypias in squamous cells (ASC), discussing its applicability to the Brazilian scenario. METHODS an electronic search of publications at PubMed, National Guidelines Clearinghouse and Scholar Google was carried out, as well as a manual search of references from the texts ...