Repeated administration of nicotine causes incentive and behavioral sensitization in animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effect of ascorbic acid administration on nicotine-induced behavioral sensitization in Male Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.25 mg/kg, i.p.) once daily for seve...

Fatty acid peroxides have been found in the atherosclerotic human aorta. Glavind found a correlation between the extent of the atherosclerotic changes and the content of lipid peroxides. These lipid peroxides are very toxic to the tissues. There are several compounds in the tissues to counteract the toxicity of peroxides in vivo, i.e. SH compounds, ascorbic acid, or tocopherol. · It may be infe...

previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. both ascorbic acid and dopamine receptor have an important role in learning and memory processes. however, the central interaction between ascorbic acid and dopamine d2 receptor on spatial learning and memory has not yet been elucidated. all experiments were carried out on mal...

Repeated administration of nicotine causes incentive and behavioral sensitization in animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effect of ascorbic acid administration on nicotine-induced behavioral sensitization in Male Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.25 mg/kg, i.p.) once daily for seve...

ABSTRACT: The history of food science, technology and nutrition and their expansion in respect of raw material, processing, finished products and nutritional value goes back to many years and is still the interests of many researchers. In this work ascorbic acid has been taken not only as an important and vital vitamin to be investigated during the course of different heat processes but also as...

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Introduction: The influence of ascorbic acid on the nicotine-induced conditioned place preference (CPP) and behavioral sensitization was investigated in the present study. Methods: In a pilot study, place conditioning and locomotor activity were investigated after nicotine (0.25, 0.5, 0.75, 1, 1.5 and 2 mg/kg) or ascorbic acid (1, 10, 100 and 1000 mg/kg) administration. Different doses of a...