Pulmonary fibrosis treatment with currently available drugs mostly seems inadequate owing to its progressive and irreversible nature. Persistent activation of underlying mechanisms primarily, oxidative-stress inflammation in lung leads pulmonary progression subsequently produces sub-therapeutic control even after prolonged drug therapy. Additionally, due large dose requirements the unavoidable ...

The late eighteenth and early nineteenth centuries saw what is known today as the Highland Clearances, which was in effect the forced migration of a large proportion of the population of the Scottish Highlands due to intensified sheep farming in the name of a more effective economic land use (Devine, 1999, pp.176-78). For the Gaelic speech community this meant ‘the removal of its heartland’ (Ma...

Ubiquitin specific protease 7 (USP7), also known as herpes virus-associated ubiquitin specific protease (HAUSP), belongs to the ubiquitin specific peptidase class of deubiquitination enzymes (Everett et al., 1997; Hu et al., 2002). It plays an important role in regulating the p53 pathway, which is critical for genomic stability and tumor suppression (Li et al., 2002). p53, one of the most impor...

Key legal developments in the last decade have significantly advanced protection for women who fear female genital cutting (FGC).1 Most notably, in 1996 forcible FGC was recognized as a severe harm constituting persecution on account of membership in a particular social group.2 A new and related question of law now presents itself to the American asylum bench. Does a parent who opposes FGC, and...

For many Deaf people born into hearing families, coming "home" into the Deaf community for the first time is a common experience and leads to a change in language use and identity. In this paper, we relate how Deaf literary artists, and specifically ASL poets, represent this experience of "coming home." The quest for a home is also a common theme which has emerged among the literatures of postc...

Why has the word “plausible” come to define federal civil litigation? In recent years, the U.S. Supreme Court supplemented longstanding pleading standards under the Federal Rules of Civil Procedure, which require a “short and plain statement of the claim,”1 to additionally require that all civil pleadings state a claim that is “plausible.”2 In Bell Atlantic Corp. v. Twombly, the Court rejected ...

The growth of e-Universities and flexible delivery in higher education may also lead to increased use of electronic course evaluation methods. The effectiveness and methodology of electronic surveys are discussed. In the graduateentry, problem-based University of Sydney Medical Program extensive use is made of web technologies for curriculum delivery and evaluation. The design and response rate...

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognosis. Leukotrienes play an important role in IPF, and leukotriene (LT)B(4) is one of the key eicosanoids in IPF. In this study, we investigated whether ONO-4057, a LTB(4) receptor (BLTR) antagonist is capable of preventing bleomycin-induced pulmonary fibrosis. On day 1, C57BL/6 male mice were given a single intratrachea...