نتایج جستجو برای: asparagine
تعداد نتایج: 8279 فیلتر نتایج به سال:
After the first isolation of asparagine in 1806 by Vauquelin and Robiquet (l), there were numerous studies of its properties and physiological significance (2-4). Piria (5) in 1848 was probably the first to adduce evidence for a physiological role of asparagine during the life cycle of plants, and also to observe its transformation or metabolism by yeast. However, it was not until approximately...
Impact of clinical and subclinical hypersensitivity to asparaginase in acute lymphoblastic leukemia.
Asparaginase is an essential element of acute lymphoblastic leukemia treatment. It depletes serum asparagine (an amino acid necessary for synthesis of cellular proteins), deprives leukemic blast cells of asparagine, and eventually results in cell death. To gain benefit from asparaginase, asparagine depletion must be ensured by giving intensive therapy and completing the full course of treatment...
We analyzed four families that presented with a similar condition characterized by congenital microcephaly, intellectual disability, progressive cerebral atrophy, and intractable seizures. We show that recessive mutations in the ASNS gene are responsible for this syndrome. Two of the identified missense mutations dramatically reduce ASNS protein abundance, suggesting that the mutations cause lo...
While glutamine is a nonessential amino acid that can be synthesized from glucose, some cancer cells primarily depend on glutamine for their growth, proliferation, and survival. Numerous types of cancer also depend on asparagine for cell proliferation. The underlying mechanisms of the glutamine and asparagine requirement in cancer cells in different contexts remain unclear. In this study, we sh...
Some asparagine and glutamine residues in proteins undergo deamidation to aspartate and glutamate with rates that depend upon the sequence and higher-order structure of the protein. Functional groups within the protein can catalyze this reaction, acting as general acids, bases, or stabilizers of the transition state. Information from specific proteins that deamidate and analysis of protein sequ...
Acrylamide is a neurotoxin and probable carcinogen formed as processing contaminant during baking production of different foodstuffs, including bread products. The amino acid asparagine the limiting substrate in Maillard reaction that produces acrylamide, so developing wheat (Triticum aestivum L.) cultivars with low free concentrations grain promising approach to reduce dietary acrylamide expos...
Asparagine (N-) linked protein glycosylation is a common and essential post-translational modification of proteins in eukaryotes, archaea and some bacteria. It plays crucial roles in protein folding and in regulation of protein function. Although the general principles of Nglycosylation have been long known, the precise details governing whether a particular asparagine residue will be N-glycosy...
Asparagine biosensor was constructed by co-immobilized anti-leukemic enzyme (L-asparaginase) and absorptive pH sensitive indicator on to plastic chips of 5mm through hydro sol-gel approach. Asparagine is used as a biomarker for detection of acute lymphoblastic leukemia. In this research work asparagine biosensor was developed focusing on L-asparaginase activity as bioassay principle. L-asparagi...
The biochemical and pharmacological effects oÃEscherichia coli asparagjnase were studied in 45 patients with leukemia and solid tumors. The drug was given in three different schedules: as a single dose, daily, or weekly. After i.v. injec tion, the peak activity obtained was dose related; the initial clearance of the enzyme from plasma followed first-order kinetics, and a half-life was about 14 ...
The biochemical and pharmacological effects oÃEscherichia coli asparagjnase were studied in 45 patients with leukemia and solid tumors. The drug was given in three different schedules: as a single dose, daily, or weekly. After i.v. injec tion, the peak activity obtained was dose related; the initial clearance of the enzyme from plasma followed first-order kinetics, and a half-life was about 14 ...
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