In this study, trypsin-like protease activity and expression of serine encoding genes (PmPPAE1, PmPPAE2 - clip-serine proteases PmTLP1, PmTLP2 proteases) in the different tissues black tiger shrimp were determined. The level PmPPAE1 was highest hemolymph; meanwhile that PmTLP1 hepatopancreas. hemolymph white spot syndrome virus (WSSV)-injected shrimp, PmPPAE1, upregulated by 2.32, 2.57 4.56-fol...

Polyserase-1 (polyserine protease-1)/TMPRSS9 (transmembrane serine protease 9) is a type II transmembrane serine protease (TTSP) that possesses unique three tandem serine protease domains. However, the physiological function of each protease domain remains poorly understood. We discovered a new splice variant of polyserase-1, termed Serase-1B, which contains 34 extra amino acids consisting a SE...

Trypsin-like activity is secreted from eggs of many species at fertilization, and this activity is believed to be critical for the block to polyspermy. Here we show that a cortical granule serine protease of sea urchins is the major and perhaps only protease family member important for fertilization. Zymography assays suggest that the cortical granules contain a single serine protease that can ...

The Plasmodium falciparum serine repeat antigen (SERA) and serine repeat protein homologue (SERPH) contain highly conserved domains that appear to encode cysteine proteases or related proteins. Humoral immune responses against the protease domains of SERA and SERPH were evaluated. Malaria-immune Africans, but not nonimmune controls, demonstrated potent humoral responses against the protease dom...