Effects of Excess NaCI Intake on Blood Pressure and Cholesterol-Induced Atherosclerosis in the Monkey • The Macaca irus is a monkey species that is highly susceptible to experimental cholesterol atherosclerosis of the aorta, coronary and cerebral arteries and cutaneous xanthomatosis-like lesions induced by feeding a diet high in cholesterol and/or coconut oil for 14 months. The monkeys fed an a...

Effects of Excess NaCI Intake on Blood Pressure and Cholesterol-Induced Atherosclerosis in the Monkey • The Macaca irus is a monkey species that is highly susceptible to experimental cholesterol atherosclerosis of the aorta, coronary and cerebral arteries and cutaneous xanthomatosis-like lesions induced by feeding a diet high in cholesterol and/or coconut oil for 14 months. The monkeys fed an a...

Five series of experiments were accomplished, utilizing a total of 190 birds. The established methods of the department's atherosclerosis research team were followed throughout. One-day old Hy-Line chicks were obtained from a commercial hatchery and reared in a battery brooder on a diet of commercial chick starter mash. At onset of the study, the birds were divided into experimental groups and ...

Plasma lipid profiles were determined in two inbred strains of mice, C57BR/cdJ and CBA/J, fed either a normal chow or an atherogenic diet for a 15-week period, starting at 10 weeks of age. On the chow diet, the C57BR/cdJ had significantly higher mean free cholesterol, esterified cholesterol, and total lipid values, and a significantly lower mean phosphatidylcholine/free cholesterol ratio than t...

We recently developed a nutritional model of steatohepatitis and metabolic syndrome in Ossabaw pigs. Here we describe changes in the serum proteome of pigs fed standard chow (control group; n = 7), atherogenic diet (n = 5), or modified atherogenic diet (M-ath diet group; n = 6). Pigs fed atherogenic diet developed metabolic syndrome and mildly abnormal liver histology, whereas pigs fed M-ath di...

BACKGROUND Diabetes mellitus (DM) is associated with a range of microvascular complications including diabetic nephropathy (DN). Microvascular abnormalities in the kidneys are common histopathologic findings in DN, which represent one manifestation of ongoing systemic microvascular damage. Recently, sidestream dark-field (SDF) imaging has emerged as a noninvasive tool that enables one to visual...

Following complete pancreatectomy, chicks exhibit an excessive hypercholesterolemia wshen fed a diet containing cholesterol plus cottonseed oil. This inordinate hypercholesterolemia is accompanied by intensified atherogenesis, compared with unoperated controls on the same diet. Dietary neutral fat is essential for these excessive cholesterolemic and atherogenic responses. The possible significa...

Methionine deficiency in the presence of a high-fat, high-cholesterol diet aggravates atherogenesis in the cockerel. High-protein, high-vitamin supplementation suppresses the atherogenic effect of a cholesterol-fat-containiiig diet. High-protein supplementation alone had a suppressive effect; high-vitamin supplementation had no effect. However, the combined protein and vitamin supplement was th...