نتایج جستجو برای: atria fibrillation
تعداد نتایج: 62691 فیلتر نتایج به سال:
Methodology for patient-specific modeling of atrial fibrosis as a substrate for atrial fibrillation.
Personalized computational cardiac models are emerging as an important tool for studying cardiac arrhythmia mechanisms, and have the potential to become powerful instruments for guiding clinical anti-arrhythmia therapy. In this article, we present the methodology for constructing a patient-specific model of atrial fibrosis as a substrate for atrial fibrillation. The model is constructed from hi...
The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming the therapy of choice for atrial fibrillation. This is inevitably associated with the obliteration of cardiac cholinergic neurons. However, the impact on ventricular elect...
In search of more efficacious and safe pharmacological treatments for atrial fibrillation (AF), atria-selective antiarrhythmic agents have been promoted that target ion channels principally expressed in the atria. This concept allows one to engage effects atria, but spares ventricles from potentially proarrhythmic side effects. It has suggested cardiac small conductance Ca 2+ -activated K + (SK...
The amount of adipose tissue that accumulates around the atria is associated with the risk, persistence, and severity of atrial fibrillation (AF). A strong body of clinical and experimental evidence indicates that this relationship is not an epiphenomenon but is the result of complex crosstalk between the adipose tissue and the neighbouring atrial myocardium. For instance, epicardial adipose ti...
Atrial fibrillation is based on various forms of congenital and acquired pathology. When choosing a method treatment, it important to understand not only the causes arrhythmia in particular patient, but also features its mechanism progression factors. Obviously, there difference mechanisms paroxysmal nonparoxysmal atrial fibrillation. Criteria methods for assessing stage possible reverse struct...
The occurrence of atrial fibrillation (AF) is associated with progressive changes in the calcium handling system of atrial myocytes. Calcium cycling instability has been implicated as an underlying mechanism of electrical alternans observed in patients who experience AF. However, the extent to which calcium-induced alternation of electrical activity in the atria contributes to arrhythmogenesis ...
Introduction Pre-ablation MR imaging of atria in patients with atrial fibrillation (AF) or flutter (AFL) is one of the most challenging applications of cardiac MRI [1]. However, knowledge of the atrial anatomy, in particular the wall thickness, is important for the subsequent ablation procedure; suboptimal ablation settings may entail a re-connection of tissue, or bear the risk of a puncture of...
Mechanisms regulating stretch response in the left ventricle are investigated in detail but not well understood in atrial myocardium. Hypertrophic growth of atrial myocardium contributes to the pathogenesis of atrial fibrillation. In this study, we sought to elucidate mechanisms of stretch-induced activation of key signaling pathways and hypertrophy-associated genes in rat atria. Stretching of ...
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different pathophysiological processes in the atria. Some aspects of the morphological and electrophysiological alterations promoting AF have been studied extensively in animal models. Atrial tachycardia or AF itself shortens atrial refractoriness and causes loss of atrial contractility. Aging, neurohumoral activ...
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