BACKGROUND Despite two decades of research, a transcatheter atrial septal defect closure device is not available for clinical use. We have designed a new superelastic Nitinol-Dacron, double-disk, self-centering, atrial septal defect closure device and studied its efficacy in a canine model of atrial septal defects. METHODS AND RESULTS Atrial septal defects were created surgically in 20 adult ...

Holt-Oram syndrome is a rare inherited disorder involving the hands, arms, and the heart. The defects involve carpal bones of the wrist and the thumb and the associated cardiac anomalies like atrial or ventricular septal defects. Congenital cardiac and upper-limb malformations frequently occur together and are classified as heart-hand syndromes. The most common amongst the heart-hand disorders ...

Atrial septal endocarditis can occur as an isolated event or in association with valvular endocarditis. It is also reported following percutaneous device closure of atrial septal defects. We present the echocardiography findings from a young man presenting with endocarditis of an abnormal mitral valve in whom endocarditis was demonstrated associated with an atrial septal defect.

A patient is described in whom extreme right ventricular hypoplasia and right-to-left shunting through an atrial septal defect occurred after relief of severe pulmonary stenosis. The ability of the hypoplastic right ventricle to deal with an increased volume load was assessed at cardiac catheterisation by occluding the atrial septal defect with a balloon tipped catheter.

Combined atrial septal defect and pulmonic or aortic stenosis are relatively uncommon conditions in adult patients, with few reported cases of percutaneous treatment. We present two patients with secundum type atrial septal defect and concomitant pulmonic or aortic stenosis and their treatment by transcatheter techniques.

Background: Cardiac conduction disorders are rare syndromes in neonates and children. According to the literature atrial septal defect, especially ostium secundum type, is associated with atrioventricular (AV) block. Wenckebach conduction heart block is very rare in a neonate; however, there is a dearth of research on the prevalence of this type of heart block regarding the neonates and pediatr...

T HE less obvious diseases occurring in the aged are often overlooked in clinical practice and have been given little mention in medical literature. Atrial septal defect has a high incidence in youth and middle age. Among individuals over the age of 50 it is the most common major congenital defect.' The refinement of diagnostic criteria is made imperative by the fact that rapidly progressive ca...

The number of left atrial transcatheter procedures performed via a transseptal (TS) approach has grown exponentially over the last 2 decades. Persistent iatrogenic atrial septal defects (iASD) after structural TS interventions are not uncommon especially when larger TS sheaths are used (25%–50% with 22 Fr sheaths). The optimal management strategy of postprocedural iASD is currently unknown. In ...

Thirty cases of atrial septal defect proved by cardiac catheterization, surgery, or post-morten examination have been investigated with the technic of intracardiac phonocar-diography, which provided precise localization of the source of heart sounds and murmurs. The site and mechanism of origin of the many auscultatory signs in uncomplicated atrial septal defect and in cases of Lutembacher's sy...