This article compares two hypotheses regarding the mechanisms responsible for aging in humans and other mammals. In the passive mechanism, aging is the result of inadequacies in maintenance and repair functions that act to prevent or repair damage from fundamental deteriorative processes. In the active mechanism, a life span management system purposely limits life span by deactivating maintenan...

Heparan sulfate proteoglycans (HSPGs) are potent regulators of vascular remodeling and repair. Heparanase is the major enzyme capable of degrading heparan sulfate in mammalian cells. Here we examined the role of heparanase in controlling arterial structure, mechanics, and remodeling. In vitro studies supported that heparanase expression in endothelial cells serves as a negative regulator of end...

Skin tissue defects have become one of the major sources mortality and morbidity among all age group people worldwide. engineering has enticed considerable heedfulness from researchers as an optimistic approach for repairing partial/ full thickness burn tissue. is a highly vascularized, bio mineralized composite material composed fibroblasts collagen surrounded by specialized extracellular matr...

Contact mechanics is related to the deformation study of solids that meet each other at one or more points. The physical and mathematical formulation of the problem is established upon the mechanics of materials and continuum mechanics and focuses on computations involving bodies with different characteristics in static or dynamic contact. Contact mechanics gives essential information for the s...

Heparan sulfate proteoglycans (HSPGs) are potent regulators of vascular remodeling and repair. Heparanase is the major enzyme capable of degrading heparan sulfate in mammalian cells. Here we examined the role of heparanase in controlling arterial structure, mechanics, and remodeling. In vitro studies supported that heparanase expression in endothelial cells serves as a negative regulator of end...

OBJECTIVE To determine how normal gait patterns may change as a result of chronic anterior cruciate ligament deficiency and subsequent reconstructive surgery. DESIGN Gait testing of 10 chronic anterior cruciate ligament deficient subjects prior to and 3 months following reconstructive surgery, and 10 uninjured controls. BACKGROUND There is controversy whether persons with chronic anterior c...

<span>The article considers the digital transformation of aviation industry based on twins maintenance and repair. As a result digitization, set documents application software are formed in virtual reality environment. The concept twin is presented context model-based system design helicopter process according to technical regulations. Based statistical modeling technologies, model for as...

Scheduling problems are NP – Hard combinatorial optimization problems, since many algorithms have been developed which offers new promising insights for solving resource allocation problems. Considering the problems faced in automobile repair shops, who sets the customer due dates of the car based on processing time, jobs already waiting for processing and mechanic available time. Also the work...