Celiac disease, a permanent, irreversible but treatable disease is an autoimmune triggered by gluten ingestion in genetically predisposed individuals, also known as celiac sprue and sensitive enteropathy. Recent findingsIntestinal inflammation villous atrophy small intestines permanent intolerance to disesea leads seveare malabsorption. About 20%-38% patients were basically nutritionally imbala...

Gluten-sensitive enteropathy or, as it is more commonly called, celiac disease, is an autoimmune inflammatory disease of the small intestine that is precipitated by the ingestion of gluten, a component of wheat protein, in genetically susceptible persons. Exclusion of dietary gluten results in healing of the mucosa, resolution of the malabsorptive state, and reversal of most, if not all, effect...

The complement is a part of the immune system that plays several roles in removing pathogens. Despite the importance of the complement system, the exact role of each component has been overlooked because the complement system was thought to be a nonspecific humoral immune mechanism that worked against pathogens. Decay-accelerating factor (DAF or CD55) is a known inhibitor of the complement syst...

For decades, generations of students have been taught that autoimmune diseases were caused by environmental factors acting on a background of variable genetic susceptibility. Numerous susceptibility genes with the potential to influence immune function have been identified [1,2], but with the exception of certain drug induced syndromes [3] and gluten sensitive enteropathy [4] evidence about the...

Celiac disease (CD) is an autoimmune disorder that occurs in genetically susceptible individuals of all ages and is triggered by immune response to gluten and related proteins. The disease is characterized by the presence of HLA-DQ2 and/or -DQ8 haplotypes, diverse clinical manifestations, gluten-sensitive enteropathy, and production of several autoantibodies of which endomysial, tissue transglu...

Celiac disease (celiac sprue or gluten-sensitive enteropathy) is an inflammatory autoimmune disease of the small intestine that occurs in genetically susceptible (HLA DQ2 or DQ8 ) individuals upon exposure to dietary gluten.1 Gluten (gliadin and glutenin, found in wheat, rye, and barley) comprises a family of prolineand glutamine-rich proteins. Celiac disease is common, affecting 0.5 to 1% of t...