Although gestational hyperthyroidism is uncommon (0.2%), hypothyroidism (autoimmune disease or suboptimal iodine intake) occurs in 2.5% of women and is predictive of reduced neonatal and child neuropsychological development and maternal obstetric complications. Postpartum thyroid dysfunction (PPTD) occurs in 5-9% of women and is associated with antithyroid peroxidase antibodies (antiTPOAb) in 1...

BACKGROUND The administration of anti-trypanosome nitroderivatives curtails Trypanosoma cruzi infection in Chagas disease patients, but does not prevent destructive lesions in the heart. This observation suggests that an effective treatment for the disease requires understanding its pathogenesis. METHODOLOGY/PRINCIPAL FINDINGS To understand the origin of clinical manifestations of the heart d...

Myasthenia gravis is a chronic autoimmune disease of neuromuscular transmission resulting in fatigable skeletal muscle weakness. Preeclampsia is a multisystem disease of pregnancy which is characterised by hypertension and involvement of one or more organ systems. Both diseases are responsible for considerable morbidity and mortality for mother and fetus. The occurrence of both preeclampsia and...

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system with an increasing incidence in females. Epidemiological data strongly implicate environmental factors acting at the population level during gestation, childhood and adulthood in the increasing incidence of MS. Several such factors are implicated in disease risk, but their causality remains unproven, wh...

Over the past century autoimmune disease incidence has increased rapidly in (post-) industrialised, affluent societies, suggesting that changes ecology and lifestyle are driving this development. Epidemiological studies show (i) 80% of patients female, (ii) diseases co-occur more often women, (iii) some is increasing faster women than men. The female preponderance autoimmunity most pronounced b...

A workshop entitled, "The Impact of Maternal Thyroid Diseases on the Developing Fetus: Implications for Diagnosis, Treatment, and Screening," was held in Atlanta, Georgia, January 12-13, 2004. This paper reports on the individual session that examined thyroid inadequacy during gestation as a risk factor for adverse pregnancy and developmental outcomes. For this session the following papers were...

Background The identification of new exploitable molecular pathogeneses (beyond the conventional amyloid hypothesis) for Alzheimer’s disease (AD) is a continuing neurotherapeutic priority, and has yielded range mechanistic proposals including immunopathy, gliopathy, mitochondriopathy, synaptopathy. However, as these hypotheses emerge, they are often regarded mutually exclusive even in competiti...