This document is disseminated under the sponsorship of the Department of Transportation, Federal Aviation Administration, in the interest of information exchange. The United States Government assumes no liability for its contents or use thereof. The U.S. Federal Aviation Administration is deploying Automatic Dependent Surveillance-Broadcast (ADS-B) to provide next-generation surveillance derive...

AIM To establish an inducible liver injury mouse model and transplant human hepatocytes to obtain liver-humanized mice. METHODS We crossed three mouse strains, including albumin (Alb)-cre transgenic mice, inducible diphtheria toxin receptor (DTR) transgenic mice and severe combined immune deficient (SCID)-beige mice, to create Alb-cre/DTR/SCID-beige (ADSB) mice, which coincidentally harbor Al...

The broadcast automatic dependent surveillance (ADS-B) system is a new-generation air traffic control designed to avoid the waste of resources in secondary radars. establishment spaceborne ADS-B provides broad prospect for ionospheric tomography. In this paper, external observation information ionosphere obtained by measuring Faraday rotation angle, that is, total electron content (TEC). Tomogr...

The senescence checkpoint constrains the proliferative potential of normal cells in culture to a finite number of cell doublings. In this study, we investigated the mechanism of cyclin dependent kinase (cdk) inhibition in senescent human prostatic epithelial cells (HPECs). Progression of HPECs from early passage to senescence was accompanied by a gradual loss of cells in S phase and an accumula...

Endocrine treatment is the current first line treatment in ER+ advanced breast cancer with a requirement of predictive biomarkers to the treatment and different approaches for endocrine resistance risk. Cyclin dependent kinases (CDKs) are regulating each step of cellular division in mammalian cell cycle and are hyperactivated in cancer cells causing cancer progression. Next generation pan-CDK i...

The present work deals with design, synthesis, mechanistic study and biological evaluation of novel, diverse compounds as potential inhibitors of cyclin-dependent kinase 2 (CDK2). Multi-complex-based method has been suggested to generate a comprehensive pharmacophore map of cyclin-dependent kinase 2 (CDK2) based on a collection of 13 crystal structures of human CDK2 inhibitor complex. The propo...

The senescence checkpoint constrains the proliferative potential of normal cells in culture to a finite number of cell doublings. In this study, we investigated the mechanism of cyclin dependent kinase (cdk) inhibition in senescent human prostatic epithelial cells (HPECs). Progression of HPECs from early passage to senescence was accompanied by a gradual loss of cells in S phase and an accumula...

The world’s airspaces are becoming increasingly crowded as manned and unmanned aircraft must coexist in the future. To handle this growth, new and more efficient protocols are being rolled out in most countries. Automatic Dependent Surveillance-Broadcast (ADS-B) is one of the core pieces of next generation air traffic management. Several publications in the academic and hacker community have hi...

The Federal Aviation Administration (FAA) Alternative Positioning Navigation & Timing (APNT) program is developing and examining solutions to provide terrestrial based radio-navigation capability that can support Next Generation Air Transportation System (NextGen) even with the loss of GNSS. Two technologies being examined are improved distance measuring equipment (DME) and passive ranging from...