Introduction: Mechanical stimulation of human mesenchymal stem cells has demonstrated changes in many cell behaviours such as adhesion, migration, growth and differentiation through mechanotransductive pathways. These include experiments on effect of nanotopography 1, shear stress, stiffness of extracellular matrix 2, strain, stress and acoustic wave energy 3 on cells. In this research we wer...

articular cartilage, the load-bearing tissue of the joint, has limited repair and regeneration ability. the scarcity of treatment modalities for large chondral defects has motivated researchers to engineer cartilage tissue constructs that can meet the functional demands of this tissue in vivo. cartilage tissue engineering requires 3 components: cells, scaffold, and environment. owning to their ...

Using an ethnically diverse longitudinal sample of 338 kindergarten children, this study examined the effects of cumulative contextual stressors on children's developing hypothalamic-pituitary-adrenocortical (HPA) axis regulation as an early life indicator of allostatic load. Chronic HPA axis regulation was assessed using cumulative, multiday measures of cortisol in both the fall and spring sea...

It is difficult to conduct cyclic tensile fatigue tests for fine ceramics because of its high brittleness, and a little eccentricity of loading axis and gripping device gives inaccurate strength data. So, a major part of cyclic fatigue tests have been carried out under bending load conditions, for the allowance of misalignment of loading axis is generous to some extent in the case of bending fa...

Osteotomy procedures around the knee can alter the biomechanical axis of the knee, thereby shifting the load from one compartment to another. This can be used to unload an arthritic painful compartment or to decrease the weight experienced by a cartilage restoration procedure. Recent clinical and biomechanical studies have emphasized the importance of correcting the weight bearing axis in a car...

The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved. Multiple genes contribute to disease susceptibility. The interaction of sex, hormonal milieu, and the hypothalamo-pituitary-adrenal axis modifies this susceptibility and the clinical express...