background: y chromosomal microdeletion is an important genetic disorder, which may arise due to intrachromosomal recombination between homologous sequences in the male specific region of the human y chromosome. it is frequently associated with the quantitative reduction of sperm. the screening for y chromosomal microdeletions has a great clinical value. objective: to develop a sequence tagged ...

background: microdeletions of the azoospermia factor locus of the long arm of y chromosome are an etiological factor of severe oligozoospermia or azoospermia. objective: the aim of this study was to investigate the prevalence of y-chromosome microdeletions in azf region and their role in infertility in pakistani population. materials and methods: the type of deletions in azf locus were detected...

Mất đoạn AZF trên nhiễm sắc thể Y là nguyên nhân gây vô sinh quan trọng ở nam giới. Mối liên giữa mất với nồng độ hormone sản và các đặc điểm lâm sàng bệnh vấn đề cần được làm sáng tỏ. Mục tiêu: khảo sát Y, dục mối một số thiểu tinh tinh. Đối tượng phương pháp nghiên cứu: chúng tôi cứu 161 Kết quả: gặp 15 (chiếm 9,3%), trong đó AZFc hay nhất. Nồng FSH, LH testosterone trung bình lần lượt là: 16...

Background & Aims: The most significant cause of infertility in men is the genetic deletion in the azoospermia factor (AZF) region that is caused by the process of intra- and inter-chromosomal homologous recombination in amplicons. Homologous recombination could also result in partial deletions in AZF region. The aim of this research was to determine the association between the partial AZFc del...

Abstract Study question To investigate which semen parameter in AZFc microdeletion patients affect the intracytoplasmic sperm injection (ICSI) clinical outcomes. Summary answer AZF-microdeletion caused oligospermia affected ICSI outcome when concentration is less than 1x106/ml. What known already reduce impact of female factors on outcomes, this study employed a propensity score matching analys...

Bovine adrenal zona fasciculata (AZF) cells express a noninactivating K 1 current (I AC ) that is inhibited by adrenocorticotropic hormone and angiotensin II at subnanomolar concentrations. Since I AC appears to set the membrane potential of AZF cells, these channels may function critically in coupling peptide receptors to membrane depolarization, Ca 2 1 entry, and cortisol secretion. I AC chan...

Reprogramming receptors to artificially respond to light has strong potential for molecular studies and interrogation of biological functions. Here, we design a light-controlled ionotropic glutamate receptor by genetically encoding a photoreactive unnatural amino acid (UAA). The photo-cross-linker p-azido-L-phenylalanine (AzF) was encoded in NMDA receptors (NMDARs), a class of glutamate-gated i...

Microdeletions in Yq are associated with defects in spermatogenesis, while those in the AZF region are considered critical for germ cell development. We examined microdeletions in the Y chromosomes of patients attended at the Laboratory of Human Reproduction of the Clinical Hospital of the Federal University of Goiás as part of a screening of patients who plan to undergo assisted reproduction. ...