C59-X (X= C, N, P, As and Sb) was studied by Density Functional Theory DFT at the B3LYP/3-21G** level. Group V elements have been selected to be substituted in the fullerene-C60 cage in order to show the effect of such substations upon structural and electronic properties of the studied molecules. It is found that elements of Group V doped C60 have an electronic structure similar to those of n-...

Human glutamate dehydrogenase isozymes (hGDH1 and hGDH2) have been known to be inhibited by palmitoyl-CoA with a high affinity. In this study, we have performed the cassette mutagenesis at six different Cys residues (Cys59, Cys93, Cys119, Cys201, Cys274, and Cys323) to identify palmitoyl- CoA binding sites within hGDH2. Four cysteine residues at positions of C59, C93, C201, or C274 may be invol...

Wnt signaling controls early embryonic hematopoiesis and dysregulated β-catenin is implicated in leukemia. However, the role of Wnts and their source in adult hematopoiesis is still unclear, and is clinically important as upstream Wnt inhibitors enter clinical trials. We blocked Wnt secretion in hematopoietic lineages by targeting Porcn, a membrane-bound O-acyltransferase that is indispensable ...

Cl6 = 0.3269 Cl7 0.7458 Cl,10 = 0.6322 C26 = 0.6428 C18 0.2978 Ci,11 = — 0.1488 C36 = 0.6725 Cl9 = 0.4364 Cl,12 = — 0.4904 C46 = 0.1488 C27 = 0.1340 C2.10 = 0 Cö6 = 0 C28 = 0.4845 C2.11 = 0 C7.10 = 0.7260 C29 = 0.6087 C2.12 = 0 C7,ll = 0.5467 y s37 = 0.3405 C3.10 = 0.6793 ^7,12 = 0.4507 C38 = 0.0394 C3. l l = 0.6793 £8,10 0.6176 C39 == 0.2440 C3.12 = 0.2151 -8.1 1 = 0.7615 C47 = 0.1087 C4,10 = ...