Journal:
:acta medica iranica
0
farhad najmeddin department of clinical pharmacy, faculty of pharmacy, tehran university of medical sciences, tehran, iran.
arezoo ahmadi department of anesthesiology and critical care medicine, sina hospital, tehran university of medical sciences, tehran, iran.
laleh mahmoudi department of clinical pharmacy, faculty of pharmacy, shiraz university of medical sciences, fars, iran.
kourosh sadeghi department of clinical pharmacy, faculty of pharmacy, tehran university of medical sciences, tehran, iran.
hossein khalili department of clinical pharmacy, faculty of pharmacy, tehran university of medical sciences, tehran, iran.
alireza ahmadvand research center for rational use of drugs, tehran university of medical sciences, tehran, iran.
high-dose extended-interval dosage (hded) regimen of aminoglycosides is now considered as the standard dosage strategy in sepsis. although safety and efficacy of this dosing regimen is well studied, but new experiments show increased the risk of resistance development associated with %t>mic less than 60% of the dosing interval following extended interval dosing. moreover, limited information is...
