The effect of a standardized extract of Bacopa monniera Linn. was assessed on rat brain frontal cortical, striatal and hippocampal superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities, following administration for 7, 14 or 21 days. The effects induced by this extract (bacoside A content 82% +/- 0.5%), administered in doses of 5 and 10 mg/kg, orally, were compar...

Three new saponins, designated as bacopasides III, IV and V have been isolated from Bacopa monniera WETTST. and their structures have been elucidated as 3-O-alpha-L-arabinofuranosyl (1-->2)-beta-D-glucopyranosyl jujubogenin (1), 3-O-beta-D-glucopyranosyl (1-->3)-alpha-L-arabinopyranosyl jujubogenin (2) and 3-O-beta-D-glucopyranosyl (1-->3)-alpha-L-arabinopyranosyl pseudojujubogenin (3) mainly o...

Brahmi(Bacopa monnieri), an Ayurvedic herb has primarily been used to enhance cognitive ability, memory and learning skills. We present a case study of schizophrenia in which add-on Brahmi extracts 500 mg/day for a period of one month resulted in reduction in psychopathology without any treatment-emergent adverse effect. Although preliminary, our case study suggests therapeutic efficacy of add-...

This study was conducted with the aim to compare two batches each of four popular commercial formulations of Bacopa monnieri (Brahmi), and report, if any, inter-batch variations. The formulations were procured from local market and analyzed for label specifications, uniformity of weight of capsule, identity, purity and strength parameters (total ash content test, acid insoluble ash content, wat...

Bilateral carotid artery occlusion followed by reperfusion produced significant cerebral infarction and impaired short-term memory, motor co-ordination and lateral push response. Individual pretreatments with chlorophyll and aqueous extracts of B. monniera and V. wallichii markedly attenuated ischaemia-reperfusion induced cerebral injury in terms of decreased infarct size, increase in short-ter...

To investigate the effect of bacosides (alcoholic extract of brahmi) on scopolamine (3 mg kg(-1), ip), sodium nitrite (75 mg kg(-1), ip) and BN52021 (15 mg kg(-1), ip) induced experimental amnesia in mice, using Morris water maze test, all the agents were administered 30 min before the acquisition trials on each day and repeated for 4 consecutive days, and on 5th day during the retrieval trials...

Theme of the present study is to evaluate neuroprotective properties of Bacopa monniera (Brahmi) extract (BME) on memory deficits and biochemical changes in ATPases system of AD induced mice. Mus musculus, of one month old weighing 20 ± 2 grams, were used as experimental model and were maintained in Animal House according to the ethical guidelines for animal protection and welfare, bearing the ...

The saponin rich fraction (SRF) of Bacopa monnieri were prepared and evaluated for in vitro immune response using murine immune cells. Thioglycollate medium elicited peritoneal exudates cells (PEC) were used to study in vitro effects of the fraction (SRF) on release of immune mediators. SRF was evaluated at different concentrations (832 – 6.5μg/ml) for release of nitric oxide (NO), superoxide (...

UNLABELLED Clinical diagnoses of Attention Deficit Hyperactivity Disorder (ADHD) and the use of prescription medications for its treatment have increased in recent years. Current treatments may involve the administration of amphetamine-type substances, a treatment path many parents are apprehensive to take. Therefore, alternative pharmacological treatments are required. Few nutritional or pharm...

Bacoside-A, a major constituent isolated from Bacopa monniera is held in high repute as a potent nerve tonic. Rats were pretreated with Bacoside A (10mg/kg and 20mg/kg body weight) for 21 days. A Parkinsonian model in rats was developed by giving 6-hydroxy dopamine (12μg/2μl in 0.1% ascorbic acidsaline) in the right striatum on 22 day. A significant protection on lipid peroxidation, glutathione...