Objective: We determined the incidence of blood culture-related sepsis, causative bacteria, and antibiotics sensitivity among newborn babies with suggestive signs sepsis admitted at Upper East Regional Hospital in Bolgatanga, Ghana.Design: Prospective cross-sectional studySetting: Newborn Care Unit Hospital, BolgatangaParticipants: Neonates to from August 2019 2020 sepsisMain outcome measures: ...

how to cite this article: khalessi n, afsharkhas l. neonatal meningitis: risk factors, causes and neurologic complications. iran j child neurol. 2014 autumn;8(4): 46-50. abstract objective neonates are at greater risk for sepsis and meningitis than other ages and in spite of rapid diagnoses of pathogens and treatments, they still contribute to complications and mortality. this study determines ...

The prompt identification of sepsis in children is challenging, but once sepsis is identified, initiation of care and determination of proper disposition may be insufficient to ensure optimal outcomes. The best opportunity for full recovery also requires rapid identification and treatment of the infectious source. Acute bacterial sinusitis is common in the pediatric population, and although int...

Nucleotide-binding oligomerization domain (NOD) 2 is a cytosolic protein that plays a defensive role in bacterial infection by sensing peptidoglycans. C5a, which has harmful effects in sepsis, interacts with innate proteins. However, whether NOD2 regulates C5a generation during sepsis remains to be determined. To address this issue, cecal ligation & puncture (CLP)-induced sepsis was compared in...

Meningococcal disease remains a significant global public health and is unique among causes of bacterial meningitis and sepsis where it not only causes sporadic disease but also outbreaks. Meningococcal disease has a rapid onset with high mortality. The understanding of immunopathogenesis is crucial for development of novel therapeutic strategies and vaccines designed against meningococcal dise...

The exact cellular and molecular mechanisms of sepsis-induced encephalopathy remain elusive. The breakdown of the blood-brain barrier (BBB) is considered a focal point in the development of sepsis-induced brain damage. Contributing factors for the compromise of the BBB include cytokines and chemokines, activation of the complement cascade, phagocyte-derived toxic mediators, and bacterial produc...

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection.1 It frequently leading death from septic shock and multi failure worldwide. can be any infection, either fungal, viral, parasitic, or bacterial, not all of these pathogens cultured. In around half patients with sepsis, no pathogen identified.2 For every hour delayed treatment the risk mortality sep...

OBJECTIVE To evaluate serial serum C-reactive protein (CRP) levels for diagnosis of neonatal infection. SETTING A regional intensive care nursery and two community intensive care nurseries. METHODS All neonates treated for suspected bacterial infection were prospectively evaluated using a standardized clinical pathway. Infants were categorized as having proven sepsis (bacteria isolated from...

background : propylene glycol (1,2-propanediol, pg) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. while pg is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. objective: to evaluate the effect of pg in sepsis induced by the bacterial endotoxin lipopolysaccharide (lp...