Protection against experimental Serratia marcescens infection in mice was enhanced by prior injection of formalin-killed or viable bacteria of the same strain. From the first to the fourth week after vaccination, specific immunity was involved in the host defence against systemic serratia infection. The transfer of antiserum specific for S. marcescens increased bacterial clearance from the live...

Bacterial mechanosensitive ion channels are responsible for cellular survival in response to rapidly changing environmental conditions such as membrane tension or osmotic shifts. In these shifts, bacterial open relieve intracellular pressure prior cell lysis. The most well studied channels, the channel of large (MscL) and small (MscS) conductance from Escherichia coli (E. coli), both gate membr...

BACKGROUND Most patients with infective endocarditis (IE) manifest fever. Comparison of endocarditis patients with and without fever, and whether the lack of fever in IE is a marker for poorer outcomes, such as demonstrated in other severe infectious diseases, have not been defined. METHODS AND RESULTS Cases from the Mayo Clinic, Rochester, Minnesota, Division of Infectious Diseases IE regist...

background and objectives:infection of pleural fluid is a common disease and because of antibiotic administration, the microbiology of this fluid has changed. the aim of this study was to determine the common bacteria and suitable antibiotics for treatment in pleural effusion (pe). materials and methods: in this cross sectional study, 1210 samples with exudative features were cultured for poss...

despite recent innovations in the laboratory diagnosis of bacterial from nonbacterial meningitis, solid data-necessary for early determination of bacterial meningitis (bm) before organism growth in the culture medium-are missing. therefore cerebrospinal fluid (csf) lactate levels were evaluated as a possible means of differentiating the two clinical entities. this was a retrospective study. pat...

BACKGROUND Circulating bacterial DNA fragment is related to systemic inflammatory state in peritoneal dialysis (PD) patients. We hypothesize that plasma bacterial DNA level predicts cardiovascular events in new PD patients. METHODS We measured plasma bacterial DNA level in 191 new PD patients, who were then followed for at least a year for the development of cardiovascular event, hospitalizat...

Antibody production and clinical efficacy (relative percent survival RPS) were measured in 40±5g rainbow trout after immunization with two types of Streptococcus iniae vaccines consisting of formalin killed cells (FKC) and FKC enriched with the bacterial extracellular products (ECP) administered by intraperitoneal (i.p), immersion and oral routes at 16±1°C for 18 weeks. No significant differenc...

Neonatal meningitis by Eschericia coli RS218 occurs due to bacteremia and its transmigration across the blood-brain barrier. Although the outer membrane protein A (OmpA), a molecule with extracellular loops has been shown to contribute to the above phenomenon, we do not know the exact the role of these individual loops. Using bacterial strains whose individual loops have been removed, we demons...