BACKGROUND Aging is a fundamental biological process. Characterization of genetic and environmental factors that influence lifespan is a crucial step toward understanding the mechanisms of aging at the organism level. To capture the different effects of genetic and environmental factors on lifespan, appropriate statistical analyses are needed. METHODOLOGY/PRINCIPAL FINDINGS We developed an on...

Eukaryotic cells can adapt to endoplasmic reticulum (ER) dysfunction by producing diverse signals from the ER to the cytosol or nucleus. These signaling pathways are collectively known as the unfolded protein response (UPR). The canonical branches of the UPR are mediated by three ER membrane-bound proteins: double-stranded RNA-dependent protein kinase (PKR)-like endoplasmic reticulum kinase (PE...

In China, the arid area occupies a quarter of the total area of the land. It mainly distributes in five provinces: Gansu, Ningxia, Qinghai, Xinjiang and Inner Mongolia. In the arid area, oasis is the special landscape on the background of deserts. It is not only the most centralized area of human activities but also the largest area where human disturbances happen at the regional scale. Oasis c...

Online application for survival analysis (OASIS) has served as a popular and convenient platform for the statistical analysis of various survival data, particularly in the field of aging research. With the recent advances in the fields of aging research that deal with complex survival data, we noticed a need for updates to the current version of OASIS. Here, we report OASIS 2 (http://sbi.postec...

Spatio-temporal integrated assessment of land-use change impacts on carbon storage services is a new and important research field in land science and landscape ecology. The objective of this paper is to use an integrated SD-CLUE-S and InVEST model to simulate and predict land-use changes impacts during 2000-2018 on carbon storage at pixel and regional scales in the Zhangye oasis, Northwest Chin...

OBJECTIVE The objective of the study was to evaluate the frequency of obstetrical anal sphincter injuries (OASIS) in women undergoing operative vaginal deliveries (OVD) and to assess whether a mediolateral episiotomy is protective for developing OASIS in these deliveries. STUDY DESIGN We performed a retrospective cohort study. Maternal and obstetrical characteristics of the 2861 women who del...

Portable and affordable assistive devices are calling necessities for the physically challenged population putting forth the requirement of designing embedded systems tuned to specific assistive applications. In this paper, we present a low footprint embedded operating system, OaSis, which forms the core of embedded devices being developed for the speech impaired, the visually impaired and thos...

The Ontological Adaptive Service-Sharing Integration System (OASIS) provides a means for reverse engineering tools to work cooperatively to share services and assist maintainers in carrying out software analysis and program comprehension tasks. OASIS makes use of specially constructed, external tool adapters and a domain ontology to facilitate integration among a set of reverse engineering tool...

Global anycast, an important building block for many distributed services, faces several challenging requirements. First, anycast response must be fast and accurate. Second, the anycast system must minimize probing to reduce the risk of abuse complaints. Third, the system must scale to many services and provide high availability. Finally, and most importantly, such a system must integrate seaml...

BACKGROUND Smoking is a modifiable lifestyle factor that has been shown to be associated with adverse perinatal outcomes and to have adverse health and dose-dependent connective tissue effects. The objective of this study was to examine whether smoking during pregnancy was associated with the incidence of obstetric anal sphincter injuries (OASIS) among six birthweight groups in singleton vagina...