Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of the early problems that hindered the clinical applications of particulate DDS have been overcome, with several DDS formulations of anticancer and antifungal drugs now approved for clinical use. Furthermore...

The Advanced Practices Council (APC) of SIM commissioned two academic researchers (Gabe Piccoli and Federico Pigni) to help members learn how best to leverage the digital data streams being created every day, both inside and outside their firms, to provide greater value to customers and their firms. Piccoli and Pigni presented their findings at the May 2012 APC meeting. A key element of their p...

In this research, a new method for market-product strategic planning is presented. In this method, an expert system is designed on the basis of identifying important factors that are effective in a firm and analyzing the logical relations between them. The objective is to develop a decision support system (DSS) for helping managers to make strategic decisions. DDS can serve as suitable replacem...

Sulfonamide- and sulfone-induced hypersensitivity reactions are thought to be mediated through bioactivation of parent drug molecule(s) to their respective reactive metabolite(s). Recent studies have demonstrated that keratinocytes can bioactivate sulfonamides and sulfones. Using enzyme-linked immunosorbent assay and hapten-specific rabbit antisera developed in our laboratory, we found that inc...

There is a serious potential risk in the petrochemical production process, the Disaster Detection System(DDS) is of key equipment to monitor the production status, prevent and control the potential risk. However, the Initiating failure and Inhibiting failure would occur in the period of the Disaster Detection System(DDS) working. In order to identify the two failures by DDS itself, the paper pr...

OMG (Object Management Group) DDS (Data Distribution Service for Real-time Systems) is an open international communication middleware standard for real-time and embedded systems. In this paper, a communication middleware model based on OMG DDS for multi-robot environments is presented. With the help of DDS QoS mechanism and Publish/Subscribe paradigm, proposed communication middleware abstracts...

In this work, polymer-drugs conjugates used as drug delivery systems (DDS) are revised attending to their chemical conjugation. Namely, the classification of this type of DDS is based on the conjugation sites of the reactive groups (i.e., via end groups or pendant polymer groups). Advantages and limitations of these types of DDS are discussed through representative examples of polymer-drugs and...

The conformational order of sodium dodecyl sulfate (SDS), sodium dodecylsulfonate (DDS), dodecyltrimethylammonium chloride (DTAC), and dodecylammonium chloride (DAC) adsorbed at the D2O/CCl4 interface has been examined by total internal reflection sum-frequency vibrational spectroscopy (VSFS). The vibrational sum-frequency spectra indicate the presence of gauche conformations in the hydrocarbon...

Proteins of the death domain (DD) superfamily mediate assembly of oligomeric signaling complexes for the activation of caspases and kinases via unknown mechanisms. Here we report the crystal structure of the PIDD DD and RAIDD DD complex, which forms the core of the caspase-2-activating complex PIDDosome. Although RAIDD DD and PIDD DD are monomers, they assemble into a complex that comprises sev...