EDITOR—Holt-Oram syndrome (HOS) is a developmental disorder characterised by malformations of the radial ray of the forelimb and by congenital heart disease. The syndrome shows a marked variability in phenotype, with radial ray defects ranging from minor thumb abnormality through to severe reduction defect or phocomelia. The cardiac manifestations of HOS are similarly varied, and patients can p...

Most men and women remain sexually active into mid-life and beyond. However, sexual functioning in periand postmenopausal women, and their partners, is widely variable. Somatic symptoms, psychological issues, partner's physical, psychological, and relationship status are all important to one's perceived quality of life, and may greatly affect sexuality. These wide-ranging influences complicate ...

Organizational citizenship behavior becomes one of the important factors that enhance the organizational effectiveness. The main purpose of this study was to explore the importance of OCB of universities teachers of Pakistan as the outcome of organizational commitment. In this study the impact of training & development opportunities, work-life policies and empowerment practices on organizationa...

•Capturing in vivo the early cellular responses to tissue injury•Identification of a common stress response signature following damage•Transcriptional changes by cell dissociation impair accuracy single-cell atlases•Cooperating MAPK and Notch signaling control quiescence exit MuSCs Tissue damage dramatically alters how cells interact with their microenvironment. These turn dictate responses, su...

Immune checkpoint inhibitors and targeted therapies have profoundly altered the management of several cancers over past decade. Metastatic melanoma has been at forefront these changes. We provide here a nationwide overview an assessment changes in survival France. included 10,936 patients receiving systemic treatment for metastatic cutaneous between 2010 2017 using French National Health Insura...

Silicon Valley is known for its amazing workspace and perks. Due to Equity Theory and Two-factor Theory, employees should be content and stay longer. However, studies have found that there's a higher rate of job-hopping, which seems like a contradiction (Fallick et al, 2006). Participants were 135 engineers, ages 18 to 35 years old, who completed an online survey looking at job satisfaction, jo...

Questionnaire-based pre/post course testing can be used to extend the cognitive processes provided in short (2to 6-hour) courses. When participants participate in preand post-course assessments and implement the changes they commit to at the end of a course, course designers can have an impact on knowledge and workplace practices. A carefully designed pre-course assessment offered prior to an e...

We describe a procedure for acquiring intonational phrasing rules for text-to-speech synthesis automatically, from annotated text, and some evaluation of this procedure for English and Spanish. The procedure employs decision trees generated automatically, using Classi cation and Regression Tree techniques, from text corpora which have been hand-labeled by native speakers with likely locations o...

The review examines a number of points of similarity and difference between males and females in relation to the human sexual response and the anatomy and functions of their respective genitalia. A variety of topics including foetal sexual differentiation, innervation of the genitalia, penis in erection and flaccidity and corresponding neurotransmitters, pelvic striated musculature, vaginal and...