OBJECTIVES The efficacy of BCG vaccination in preterm babies is unknown, and available data on conversion rates to tuberculin in this age group are scarce and controversial. This study assessed the tuberculin response in preterm infants after BCG vaccination. METHODS This randomized cohort study was carried out at the Neonatal Department, University Hospital, Federal University of Minas Gerai...

Background: BCG vaccination which is administered to prevent tuberculosis is sometimes associated with serious complications. This study aimed to determine the incidence of complications of BCG vaccination in Babol. Methods: All infants who received BCG vaccination between 2011-2013 in health centers of Babol entered the study. Data regarding complications of vaccine were extracted according...

Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine approved for prevention of tuberculosis. It has been postulated that serial passage of BCG over the years may have resulted in attenuation of its effectiveness. Because interleukin-12 (IL-12) and oligodeoxynucleotides (ODN) containing cytidine phosphate guanosine (CpG) motifs have been shown to enhance Th1 responses in vivo,...

To determine the effect of intrauterine growth retardation (IUGR) on the response to BCG vaccination, we evaluated the specific delayed tuberculin hypersensitivity of 57 full-term infants with symmetric IUGR (SGA or small for gestational age) and 52 full-term infants with normal intrauterine growth (AGA or appropriate for gestational age). The infants were evaluated using post-vaccination skin ...

background and objective: bcg vaccination is used in many countries with a high prevalence of tb to prevent childhood tuberculosis meningitis and miliary disease. local and systemic sideeffects are associated with bcg vaccine. the most critical reaction is disseminated bcg infection which occurs in mostly immunodeficient patients. materials and methods: we performed 4 autopsies during 2001-2003...

Bacillus Calmette-Guérin (BCG), the most common vaccine worldwide, has broad effects on the immune system. Hookworm infections are a major source of morbidity. In response to a preliminary report of BCG vaccination protection against nematodes in human immunodeficiency virus-infected adults, data from an ongoing prospective study were analyzed to determine the intensity (eggs per gram of stool)...

Bacille Calmette Guérin (BCG) is effective to prevent miliary and meningeal TB in infants [1]. The reports about the efficacy of this vaccine for the prevention of adults pulmonary TB are contradictory and the consensus is that the protection conferred by BCG against this form of TB is questionable [1]. The wide use of BCG vaccination has been unable to prevent nearly two million deaths associa...

Tuberculosis, a major public health problem is an important cause of childhood morbidity and mortality in developing countries. BCG vaccination is recommended by World Health Organization for control of disease in countries with a high incidence of tuberculosis(l). This policy is routinely applied in preterm infants who may be at a greater risk of infection than term infants. That is why like t...

I reviewed in 1952 the literature on freeze-dried BCG vaccine in order to help evaluate the relative merits of fresh liquid and dried vaccines on the basis of the results of vaccination. More BCG production centres have since taken to the preparation of dried BCG vaccine for either experimental use or for vaccination. In India, the scene of activity of the mass vaccination campaign has shifted ...

BACKGROUND The accurate diagnosis of latent tuberculosis infection (LTBI) is an important component of any tuberculosis control programme and depends largely on tuberculin skin testing. The appropriate interpretation of skin test results requires knowledge of the possible confounding factors such as previous BCG vaccination. Uncertainty about the effect of BCG vaccination on tuberculin skin tes...