BACKGROUND Polybrominated diphenyl ethers (PBDEs) are flame-retardant chemicals that are added to many consumer products. Multiple animal studies have shown PBDEs to be thyroid hormone (TH) disruptors. Epidemiologic evidence of PBDE exposure associated with TH disruption has been inconclusive. OBJECTIVES We used repeated measures to estimate associations between serum PBDE concentrations and ...

Polybrominated diphenyl ethers (PBDEs) and 2,2',4,4',5,5'-hexabromobiphenyl (BB-153) are chemicals known as brominated flame retardants. We have assessed the exposure status of the United States population to PBDEs and BB-153 and explored associations with demographic information, including participants' age, sex, and race/ethnicity. A total of 2,062 serum samples, from participants in the Nati...

Introduction Polybrominated diphenyl ethers (PBDEs) are used in large quantities as additive flame retardants in plastics and textile materials. PBDEs can accumulate in the environment and have been detected in wildlife and in human adipose tissue and plasma samples. The congeners 2,2 ́,4,4 ́tetraBDE (BDE-47), 2,2 ́,4,4 ́,5-pentaBDE (BDE-99), and 2,2 ́,4,4 ́,6-pentaBDE (BDE-100) are generally the dom...

2,2,4,4-Tetrabromodiphenyl ether (BDE-47), one of the persistent organic pollutants, seriously influences the quality of life; however, its pathological mechanism remains unclear. Troxerutin is a flavonoid with pharmacological activity of antioxidation and anti-inflammation. In the present study, we investigated troxerutin against BDE-47-induced kidney cell apoptosis and explored the underlying...

To date, no report was concerned with participation of reactive oxygen species in waters during photolysis of low-brominated diphenyl ethers (LBDEs). Herein, we found that electron spin resonance (ESR) signals rapidly increased with increasing irradiation time in the solution of LBDEs and 4-oxo-TMP solutions. But this phenomenon did not occur in the presence of NaN3 (1O2 quencher) demonstrating...

24 Fourteen tri-deca polybrominated diphenyl ethers (PBDEs) were investigated in 35 human 25 milk samples from Birmingham, UK. While none of the hepta-nona BDEs (the main 26 components of the OctaBDE technical mixture) were above the limit of quantitation (LOQ); 27 BDE-47 (average concentration = 3.3 ng g lipid weight (lw)) was quantified in all samples 28 contributing 34-74% to Σtri-hexa BDEs ...

Seven species of teleost fishes comprising major prey of northwest Atlantic harbor seals were analyzed for polybrominated diphenyl ethers (PBDEs). PBDE concentrations in whole fish samples (n=87) were compared with those measured previously in harbor seal blubber to evaluate the transfer of PBDEs from prey to predator. Hexabromocyclododecane (HBCD) concentrations were measured in three fish spe...

A mass budget of polybrominated diphenyl ethers (PBDEs) in San Francisco Bay is developed as a first step towards understanding the local sources and transport processes controlling PBDE fate in a highly urbanized estuary. Extensive monitoring of PBDEs in estuarine water and sediment, freshwater tributaries, air, and wastewater effluents and sludges were integrated with a mass budget model to p...

Polybrominated diphenyl ethers (PBDEs), due to their widespread usage as flame retardants and their lipophilicity and persistence, have become ubiquitous in the environment. It is urgent to understand the environmental characteristics of PBDEs in marine system, but they have attracted little attention. We summarize the available data and analyze the regional distributions, controlling factors, ...