A Shallow foundation on cohesionless soil cannot support greater weights; piled raft foundations are recommended because they combine the load-bearing qualities of piles and raft. Combined Piled Raft Foundations (CRPF) efficient for tall buildings account both vertical lateral loads. In a pile foundation, raft’s load-resistance is disregarded due to soil-structure interaction. Simplification ma...

Advances in friction materials are imposed on developing multiceramic reinforced hybrid nanocomposites with superior tribomechanical properties. The silver-based matrix metals gained significance various applications like bearing, ratchet, and electrical contacts due to their high frictional resistance good thermal chemical stability compared traditional metals. present research is develop cont...

With the extensive application of doxorubicin (DOX), DOX resistance has become one of the main obstacles to the effective treatment of breast cancer. In this paper, DOX and resveratrol (RES) were co-encapsulated in a modified PLGA nanoparticle (NPS) to overcome the DOX resistance. CLSM results indicated that DOX and RES were simultaneously delivered into the nucleus of DOX-resistant human breas...

Aeromonas salmonicida subsp. salmonicida, the causative agent of furunculosis in salmonids, is an issue especially because many isolates of this bacterium display antibiotic resistances, which limit treatments against the disease. Recent results suggested the possible existence of alternative forms of pAsa4, a large plasmid found in A. salmonicida subsp. salmonicida and bearing multiple antibio...

In staphylococci, inducible macrolide-lincosamide-streptogramin B (MLS(B)) resistance is conferred by the erm(C) or erm(A) gene. This phenotype is characterized by the erythromycin-clindamycin "D-zone" test. Although clindamycin appears active in vitro, exposure of MLS(B)-inducible Staphylococcus aureus to this antibiotic may result in the selection of clindamycin-resistant mutants, either in v...

This paper presents the effect of geogrid tensile strength by calculating pullout resistance and geogrid-soil interaction mechanism. In order to investigate this interface, a series of pullout tests have been conducted by large scale reformed direct shear test apparatus in both cohesive and granular soils. In numerical, finite difference software FLAC3D has been carried out on experimental test...

Newly synthesized 1,4-dihydropyridine derivatives (NK-compounds) were screened to determine whether they could overcome vincristine (VCR) resistance in VCR-resistant (P388/VCR) leukemia-bearing mice. Among the 57 NK-compounds examined, six compounds had strong reversing ability (Grade A), 18 partially overcame the resistance (Grade B), and 33 did not reverse the resistance (Grade C). The abilit...