The aim of this work was to study the ability of beta-cyclodextrin (beta-CD) or hydroxypropyl beta-cyclodextrin (HP-beta-CD) to ameliorate the induction of gastric ulcers by a nonsteroidal anti-inflammatory drug, indomethacin or piroxicam, in rats exposed to restraint and hypothermic stress at 4 degrees C. Using oral gavage, rats fasted for 72 h were administered the equivalent of a 100 mg/kg d...

A beta-cyclodextrin anthracene rotaxane was synthesized and found to be significantly more resistant to fluorescence quenching and photobleaching than the uninsulated anthracene derivative.

Different supports for high-performance liquid chromatography are prepared by using the coating technology. These supports are based on silica beads coated with a beta-cyclodextrin-containing poly(vinylamine). Surface area, pore size distribution, and solid-state nuclear magnetic resonance are used for the characterization of these supports. The two different methods of preparation used lead to...

Pseudorotaxane formed by reacting beta-cyclodextrin bearing a phenylboronic acid residue with 1-heptyl-4-(4'-dimethylaminostyryl)pyridinium functioned as a novel fluorescent saccharide receptor having unique responses.

Water-based propolis extracts usually contain up to 10-fold lower quantities of active ingredients due poor solubility in water bioactive compounds when compared with ethanol-based extracts. Since are limited use, water-based preferred nowadays. The application alternative extraction techniques should be evaluated improve efficiency. Aqueous were prepared using purified and propylene glycol, 2-...

Dopamine can be detected selectively in the presence of ascorbate at a gold electrode modified by a beta-cyclodextrin/thioctic acid mixed monolayer.

Water-soluble poly(phenylene ethynylene) carrying beta-cyclodextrin was prepared; the polymer exhibited a fluorescence color change or quenching, depending on the kind of guest.

Aims: Oridonin is a new anti-tumor drug candidate with promising broad spectrum antitumor activity. The aim of the present study is to investigate the singleand repeated-dose pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complexin rats. Materials and methods: Rats were given singleor multiple-dose (7 days) of injectable beta-cyclodextrin-oridonin inclusion complex (single-...

A basis for the insulin mimetic effect of sphingomyelinase on glucose transporter isoform GLUT4 translocation remains unclear. Because sphingomyelin serves as a major determinant of plasma membrane cholesterol and a relationship between plasma membrane cholesterol and GLUT4 levels has recently become apparent, we assessed whether GLUT4 translocation induced by sphingomyelinase resulted from cha...

To expand the application of a drug in orally disintegrating tablets, the potential use of beta-cyclodextrin (beta-CyD) and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) as excipients for the tablets containing dl-alpha-tocopheryl acetate (VE), an oily drug, was evaluated. HP-beta-CyD, not beta-CyD, solubilized VE in water through the formation of higher order of complexes at the molar ratio ...