This experimental study was carried out to investigate the effect of medical grade calcium sulphate and β-tricalcium phosphate/ hydroxyapatite on new bone formation. Additionally, the study compared these materials for infection, resorption, biocompatibility, immune reaction, fi brotic encapsulation, foreign body reaction and physical attachment. Forty, fi ve-month-old female Wistar Albino rats...

Calcium Phosphate cement has been the subject of intense investigation over the past few years. This study compares difference in biocompatibility between the three main phases of Ca-P, namely Hydroxyapatite, Dicalcium phosphate and β-Tricalcium phosphate. It involves composite preparation followed by cell test. Material parameters were stoichiometry (Hydroxyapatite with Ca-P ratio of 1.67, Dic...

Background/Aim The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bone regeneration is based on the use of osteoinductive autogenous grafts as wel...

Adipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiation of ADSCs were investigated. The hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite sca...

Cytotherapy for bone regeneration has not been widely used clinically. A new method based on enriched bone-marrow-derived mesenchymal stem cells (MSCs) combined with porous beta-tricalcium phosphate (beta-TCP) was used for posterior spinal fusion in 41 patients. The aim of the present study was to assess the clinical feasibility of peri-operative bone marrow stem cell enrichment and their combi...

Biphasic calcium phosphate ceramics (BCP) comprising a mix of non-resorbable hydroxyapatite (HA) and resorbable beta-tricalcium phosphate (beta-TCP) are particularly suitable materials for synthetic bone substitute applications. In this study, HA synthesised by solid state reaction was mechanically mixed with beta-TCP, then sintered to form a suite of BCP materials with a wide range of HA/beta-...

The purpose of this prospective controlled study was to compare healing quality following the implantation of ultraporous β-tricalcium phosphate, containing either expanded autologous mesenchymal stromal cells (trial group, 9 patients) or β-tricalcium phosphate alone (control group, 9 patients), into femoral defects during revision total hip arthroplasty. Both groups were assessed using the Har...

This study was to evaluate the acid-buffering capacity and antibacterial properties of orthodontic adhesives containing bioactive glasses (BAGs) (45S5, 45S5F, S53P4), Hydroxyapatite, beta-tricalcium phosphate, Canasite. Fillers comprising 15 wt% glasses, HAp, β-TCP, Canasite incorporated with 55 silanated glass were added a mixture UDMA/TEGDMA. Acid-buffering tested by exposing disc-shaped samp...