Cryptococcus neoformans is a pathogenic yeast that often causes devastating meningoencephalitis in immunocompromised individuals. We have previously identified the C. neoformans CPS1 gene, which is required for a capsular layer on the outer cell wall. In this report, we investigate the function of the CPS1 gene and its pathogenesis. We demonstrated that treatment of yeast with either 4-methylum...

BACKGROUND We developed an experimental model of ethanol-induced dermatotoxicity and hepatocytoxicity using normal human keratinocytes and normal human hepatocytes that preserve inducible cytochrome p450 activities. The original work was described in several articles. The objective of this study was to determine whether hyaluronic acid attenuates skin necrosis, and to further clarify its uses i...

Solutions made by homogenization of vitreous humor exhibit anomalous viscosity at low shear rates due to interaction between hyaluronic acid and a hydroxyproline-containing material similar to collagen. The latter can be removed by filtration or centrifugation to give a solution whose viscosity is due to hyaluronic acid. On concentration the viscosity of the latter remains independent of shear ...

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background: various approaches have been used in the attempts to improve the quality of frozen–thawed mouse sperms. according to literatures, it seems that hyaluronic acid (ha) has an important role on the permeability and motility of sperms and their interaction with gametes. objective: for evaluation of ha supplementation on sperm characteristics and fertilization capability, we investigated ...

Antibiotic-loaded carriers were developed to fill cavities and locally deliver antibiotics following implantation. However, the most commonly used antibiotic carrier, polymethyl methacrylate (PMMA), has many disadvantages including that it does not promote bone regeneration or conduction. Vancomycin-loaded bone-like hydroxyapatite/poly amino acid (V-BHA/PAA) was successfully fabricated by a hom...

Previous reports from this laboratory demonstrated the synthesis of hyaluronic acid by a cell-free preparation obtained from a strain of Group A streptococcus. The enzymic activity which sedimented at 105,000 x g, but not at 10,000 x g, required the addition of uridine diphospho-N-acetylglucosamine, uridine diphosphoglucuronic acid, and Mg++ for the formation of hyaluronic acid (l-3). Since hya...

The main object of this paper is to report measurements made on a small series of human synovial fluids and on a few sheep and ox fluids. These measurements were made in order to test the two methods suggested by Ogston & Stanier (1953 a) for detecting differences of the specific properties of the hyaluronic acid as it occurs in synovial fluids. These methods, both of which are based on viscosi...

Introduction: Hearing loss is fairly a common disorder which is usually treated with corticosteroids via systemic administration and/or intra-tympanic injection. This study aimed to compare the effectiveness of intra-tympanic injections of dexamethasone with its combination with hyaluronic acid in patients with sudden sensorineural hearing loss.   Materials and Methods: In this clinical trial, ...

Section on Tissue Biophysics and Biomimetics, NICHD, National Institutes of Health, 13 South Drive, Bethesda, MD 20892, USA E-mail: [email protected] Summary: Aggrecan is a charged biopolymer whose complexes with hyaluronic acid provide the compressive resistance of cartilage. In cartilage extracellular matrix aggrecan-hyaluronic acid complexes are enmeshed within a network of collagen fibr...