in this paper, we prove the strong uniform consistency and asymptotic normality of the kernel density estimator proposed by jones [12] for length-biased data.the approach is based on the invariance principle for the empirical processes proved by horváth [10]. all simulations are drawn for different cases to demonstrate both, consistency and asymptotic normality and the method is illustrated by ...

Biomass is a fundamental measure in the natural sciences, and numerous models have been developed to forecast timber and fishery yields, forest carbon content, and other environmental services that depend on biomass estimates. We derive general results that reveal how dynamic models that simulate growth as an increase in a linear measure of size (e.g., diameter, length, height) result in biased...

Background: The use of dendritic cells (DCs) as a cellular adjuvant provides a promis-ing approach in immunotherapy of cancer. It has been demonstrated that Listeria mono-cytogenes activated DCs pulsed ex vivo with tumor antigens trigger a systemic Th1-biased specific immune response and a single dose of this vaccine will cause a consider-able anti tumor immunity. Objective: The present study w...

Dispersal among ecological communities is usually assumed to be random in direction, or to vary in distance or frequency among species. However, a variety of natural systems and types of organisms may experience dispersal that is biased by directional currents or by gravity on hillslopes. We developed a general model for competing species in metacommunities to evaluate the role of directionally...

In Anopheles gambiae, sex-regulated genes are responsible for controlling gender dimorphism and are therefore crucial in determining the ability of female mosquitoes to transmit human malaria. The identification and functional characterization of these genes will shed light on the sexual development and maturation of mosquitoes and provide useful targets for genetic control measures aimed at re...

Due to its ability to compensate for signals lost following therapeutic MAPK-inhibition, insulin-like growth factor type 1 receptor (IGF-1R) co-targeting is a rational approach for melanoma treatment. However IGF-1R conformational changes associated with its inhibition can preferentially activate MAPK-pathway in a kinase-independent manner, through a process known as biased signaling. We explor...

In recent years, social scientists have increasingly turned to matching as a method for drawing causal inferences from observational data. Matching compares those who receive a treatment to those with similar background attributes who do not receive a treatment. Researchers who use matching frequently tout its ability to reduce bias, particularly when applied to data sets that contain extensive...