BACKGROUND Pheochromocytomas are catecholamine producing tumors that classically present with the triad of sweating, palpitations and headache. CASE CHARACTERISTICS 9-year-old boy whose only presenting complaints were polyuria and polydipsia for 2 years. OBSERVATION Routine measurement of blood pressure detected mild hypertension, and subsequent investigations revealed bilateral pheochromoc...

A 12-year old dog with a 9-year history of primary adrenal insufficiency was referred to the service for hyporexia, muscle weakness, polyuria and polydipsia. Ultrasound examination showed an unresectable mass in the left adrenal gland, with local vascular invasion, which prompted the euthanasia of the animal. Additionally, necropsy revealed a nodular lesion in the right adrenal gland and enlarg...

Pheochromocytoma is a rare catecholamine-secreting tumour typically arising within the adrenal medulla. It may occur sporadically or be associated as part of a tumour syndrome including Von Hippel Lindau (VHL), Multiple Endocrine Neoplasia (MEN) 2 and Neurofibromatosis Type 1. VHL is associated with multi-organ involvement of benign and malignant tumours characterized by the presence of retinal...

Multiple endocrine neoplasia (MEN) type 2A, a dominant inherited syndrome caused by germline activating mutations in the RET protooncogene, is characterized by association of medullary thyroid carcinoma, pheochromocytoma and primary hyperparathyroidism. There is limited data on this disease in the Middle East region. In this paper, we present clinical and genetic studies of an Iranian patient a...

Introduction Composite pheochromocytoma is a rare tumor, occurring in only 3% of pheochromocytomas. We report case composite with neurofibromatosis type 1. Case presentation A 42-year-old man was referred to our department for further evaluation an incidentally detected right adrenal tumor. He patient at another hospital The serum and urinary catecholamine levels exceeded the normal range. Abdo...

Background Inherited cancer syndromes associated with acoustic neuroma (i.e. neurofibromatosis 2-NF2), pheochromocytoma (i.e. Von Hippel Lindau, NFl, multiple endocrine neoplasia syndromes, and hereditary paraganglioma syndrome), and colon cancer are well known. Lynch syndrome is the most common hereditary colon cancer syndrome and is caused by DNA mismatch repair dysfunction secondary to inher...

Background: Posterior reversible encephalopathy syndrome (PRES) is a neuroradiological syndrome characterized by headache, altered mental status, visual disturbance, and seizures with diagnostic MRI features, especially in the territories of posterior circulation. Reversibility of clinical and radiologic findings is generally regarded as a defining feature of PRES. Case Report: A 72-year old ma...

Pheochromocytomas can be a part of familial neoplastic syndromes, in which case they tend to be multiple and involve both adrenal glands. Therefore, sparing adrenocortical function represents a major concern while dealing with these hereditary lesions. Herein, we describe the clinical characteristics and the management strategy of a patient with von Hippel-Lindau (VHL) disease who had multiple,...

Abstract Background: We will describe a Brazilian family whose index case had pheochromocytoma and in the evaluation of genetic panel by Next Generation Sequence (NGS), germline pathogenic variants TMEM127 TP53 genes were identified. Clinical Case: A 32-year-old female patient with clinical picture paroxysms difficult to control arterial hypertension, personal history stroke acute myocardial in...

Pheochromocytoma in elderly people is a very rare disease and surgical removal the only cure. Here we present an 81-year-old gentleman with multiple co morbidities left adrenal incidentaloma. He was diagnosed to have pheochromocytoma biochemical evaluation. underwent laparoscopic adrenalectomy after prolonged preparation alpha beta blockers. This second oldest patient histo-pathological diagnos...