Background: The present study has been designed with the aim of evaluating A-kinase anchoring proteins 3 (AKAP3)and Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3) gene mutations and prediction of 3D proteinstructure for ligand binding activity in the cases of non-obstructive azoospermic male.Materials and Methods: Clinically diagnosed cases of non-obstructive azoos...

Structural and biochemical studies of the severe acute respiratory syndrome (SARS)-CoV-2 spike glycoproteins complexes with highly potent antibodies have revealed multiple conformation-dependent epitopes highlighting conformational plasticity proteins capacity for eliciting specific binding broad neutralization responses. In this study, we used coevolutionary analysis, molecular simulations, pe...

Keywords: (hACE2), Angiotensin-Converting Enzyme-2 (ACE2), Peptides, Small molecules, Receptor-Binding Domain (RBD), Immunogenicity, Proteins, Solubility, Unsuitability, Drug, Inhibition PPI, Disruptors

Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the isomerisation of proline peptide bonds to promote folding and re-folding peptides proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins parvulins. Individual PPIases overexpressed in a number cancers [62], members targetted for immunosuppressant effects.

preDQ is a software tool for peptide binding prediction to HLA-DQ2 and HLA-DQ8 proteins specially designed developed the European Food Safety Authority. The able identify peptides and/or predict their affinities. used assess risk of novel cause celiac disease. Predictions made by are based on five models assessment reported outputs. using datasets known non-binding proteins. compiled from liter...

Abstract Odorant-binding proteins (OBPs) in insects bind to volatile chemical cues that are important regulating insect behavior. It is hypothesized OBPs with specificity certain volatiles and may help transport delivery odorant receptors (ORs), buffering the olfactory response aid various behaviors. Honeybees eusocial perceive strongly rely on them perform complex Here, we have identified anno...

Cell-Selective Spider Silk Proteins In article number 2202660, Vanessa Tanja Trossmann and Thomas Scheibel design recombinant spider silk proteins to guide cell-specific materials interactions. The fusion of with short peptides from extracellular matrix such as KGD yield cell type selective binding, which enables the development hierarchically organized tissues.

background: bone morphogenetic proteins (bmps) belong to the transforming growth factor-β (tgf-β) superfamily, and play an important role in bone metabolism. recombinant forms of bmp-2 and bmp-7 are the only bmps used clinically. in this study the mature part of human bone morphogenetic protein-7 (bmp-7) was engineered through substitution of the bmp-7 n-terminal sequence by heparin-binding sit...

Abstract Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs), but specific interaction with and regulation by PIPs for most PH domain-containing proteins unclear. Here we employ a single-molecule pulldown assay study interactions of lipid vesicles full-length in mammalian whole cell lysates. Of 67 human initially examined, 36 (54%) found have affinity various specific...