OBJECTIVES Extension of the standard model while retaining compliance with it is a challenging issue because there is currently no method for semantically or syntactically verifying an extended data model. A metadata-based extended model, named CCR+, was designed and implemented to achieve interoperability between standard and extended models. METHODS Furthermore, a multilayered validation me...

A rapid high-performance liquid chromatographic bioanalytical method has been developed and validated for capecitabine in human plasma. Capecitabine a prodrug of 5-fluorouracil (5-FU), is an oral tumor – selective fluoro pyrimidine carbamate approved in the treatment of colorectal and breast cancer. Capecitabine was found with symmetrical peak shapes on an analytical column, Phenomenex Luna C18...

Metabolomics is the latest of the "omic" technologies that involves comprehensive analysis of small molecule metabolites of an organism or a specific biological sample. Metabolomics provides an insight into the cell status and describes an actual health condition of organisms. Analysis of metabolome offers a unique opportunity to study the influence of genetic variation, disease, applied treatm...

Accelerator Mass Spectrometry is a mass spectrometric method of detecting long-lived radioisotopes without regard to their decay products or half-life. The technique is normally applied to geochronology, but is also available for bioanalytical tracing. AMS detects isotope concentrations to parts per quadrillion, quantifying labeled biochemicals to attomole levels in milligram-sized samples. Its...

Objective: Acrylamide is a carcinogenic compound that can be found in commonly consumed foods and cigarette smoke. This metabolized by cytochrome P450 the human body to more reactive metabolite, glycidamide. study aimed optimize validate sensitive HPLC-UV method for determining acrylamide glycidamide simultaneously volumetric absorptive microsampling (VAMS) sample. Methods: Isoniazid as an inte...

A simple, accurate, precise and sensitive HPLC method with UV detection was developed and validated to separate and detect lamivudine in human plasma using Stavudine as an internal standard.Lamivudine (3-TC) and Stavudine (internal standard) were extracted from human plasma using methanol protein precipitation and were chromatographed on a Phenomenex C18 (250X4.6mm.,5mμ particle size) column us...

Testing for (1→3)-beta-D-glucan (BDG) is used for detection of invasive fungal infection. However, current assays lack automation and the ability to conduct rapid single-sample testing. The Fungitell assay was adopted for automation and evaluated using clinical samples from patients with culture-proven candidemia and from culture-negative controls in duplicate. A comparison with the standard as...

In this text we will formalise a novel solution, the Bayesian Volumetric Map (BVM), as a framework for a metric, short-term, egocentric spatial memory for multimodal perception of 3D structure and motion. This solution will enable the implementation of top-down mechanisms of attention guidance of perception towards areas of high entropy/uncertainty, so as to promote active exploration of the en...