Microplastics (MPs) are prevalent in marine ecosystems. Because toxicants (termed here "co-contaminants") can sorb to MPs, there is potential for MPs to alter co-contaminant bioavailability. Our objective was to demonstrate sorption of two co-contaminants with different physicochemistries [phenanthrene (Phe), log10Kow=4.57; and 17α-ethinylestradiol (EE2), log10Kow=3.67] to MPs; and assess wheth...

the fouling barnacle amphibalanus improvisus is a cosmopolitan biomonitor of trace metal bioavailability in coastal waters of reduced salinity such as estuaries or the baltic sea. bioavailability of ag, as, cd, co, cr, cu, fe, mn, ni, pb, v and zn to a. improvisus was investigated in july 2014 at 15 sites along the iranian coast of the understudied, yet biologically unique, caspian sea. in gene...

The fouling barnacle Amphibalanus improvisus is a cosmopolitan biomonitor of trace metal bioavailability in coastal waters of reduced salinity such as estuaries or the Baltic Sea. Bioavailability of Ag, As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, V and Zn to A. improvisus was investigated in July 2014 at 15 sites along the Iranian coast of the understudied, yet biologically unique, Caspian Sea. In gene...

In this chapter we review and discuss the commonly used phrase or concept "bioavailability". This concept is key to Risk Assessment as it assesses what proportion of a contaminant present at a contaminated site is available for uptake by organisms and is thus potentially able to cause harm. Whilst this is a relatively straightforward concept the reader will discover that in reality life is not ...

BACKGROUND Magnetic resonance imaging (MRI) may be a useful adjunct to current methods of evaluating renal function. MRI is a noninvasive imaging modality that has the ability to evaluate the kidneys regionally, which is lacking in current clinical methods. Other investigators have evaluated renal function with MRI-based measurements, such as with techniques to measure cortical and medullary pe...

Maize is one of the most important cereal crops for human consumption, yet it is of concern due to its low iron bioavailability. The objective of this study was to determine the effects of processing on iron bioavailability in common maize products and elucidate better processing techniques for enhancing iron bioavailability. Maize products were processed to represent different processing techn...

The aim of the present investigation was to compare pharmacokinetic profile (bioavailability) of aceclofenac by transdermal and oral application. Nanoemulsion, nanoemulsion gel and marketed tablet (Aceclofar®) were subjected to pharmacokinetic (bioavailability) studies on Wistar male rats. Several pharmacokinetic parameters like Cmax, tmax, AUC0→t, AUC0→α, Ke, and T1/2 were determined for each ...

Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. The improved bioavailability is reflected in various pharmacokinetic parameters viz. tmax, Cmax, t(1/2) and AUC, of these antibiotics. The increased bioavailability could be attributed to the effect of p...

Keyphrases D Pharmaceutical salts-general pharmacy, physicochemical properties, bioavailability, pharmaceutical properties, toxicology, review J:J Salts, pharmaceutical-general pharmacy, physicochemical properties, bioavailability, pharmaceutical properties, toxicology, review J:J Physicochemical properties-dissolution, solubility, stability, and organoleptic properties of pharmaceutical salts,...