Immunotherapy with checkpoint inhibitors Pembrolizumab shows potential to be used as a first-line in cancer treatment. A biodistribution study could maximize efficacy and minimize the risk of Therefore, it is necessary describe 89Zr-Pembrolizumab. This aims create mathematical model explain how 89Zr-pembrolizumab distributed body. Biodistribution data from Biokinetic 89Zr-Pembrolizumab NSG mice...

Despite the high incidence of inner ear disorders, there are still no dedicated medications on market. Drugs currently administered by intratympanic route, safest way to maximize drug concentration in ear. Nevertheless, therapeutic doses ensured for only a few minutes/hours using solutions or suspensions. The passage through middle barrier strongly depends physicochemical characteristics. For p...

BACKGROUND Preclinical research implementing fluorescence-based approaches is inevitable for drug discovery and technology. For example, a variety of contrast agents developed for biomedical imaging are usually evaluated in cell systems and animal models based on their conjugation to fluorescent dyes. Biodistribution studies of excised organs are often performed by macroscopic imaging, whereas ...

We present the case of a 61-year-old man who underwent I-123 metaiodobenzylguanidine (MIBG) scintigraphy based on clinical suspicion of pheochromocytoma. The study was nondiagnostic secondary to diffuse muscle uptake. On review of his medications, the patient was found to be taking mirtazapine, a tetracyclic antidepressant (Remeron). We hypothesize that the MIBG biodistribution was altered by m...

Bispecific and bifunctional antibodies are attracting considerable interest as innovative anti-cancer therapeutics, but their ability to selectively localize at the tumor site has rarely been studied by quantitative biodistribution studies in immunocompetent animal models or in patients. Here, we describe the production of a novel bifunctional antibody, consisting of the F8 antibody (specific t...


 Purpose: To evaluate the characteristics and biodistribution of trans resveratrol-PEG-folic acid-gold nanoparticle conjugates (rsv-PEG-FA-AuNP).
 Methods: Gold nanoparticles were produced by citric reduction followed conjugation PEG-folic acid resveratrol. Characterization rsv-PEG-FA-AuNP including their particle size, zeta potential, Fourier transform infrared spectroscopy (FTIR), ...