For many years the only drugs licensed for the treatment of multiple sclerosis (MS) were administered by injection (interferon beta, glatiramer and ▼natalizumab). Recently, three oral drugs have become available. We have previously reviewed the use of ▼fingolimod for highly active relapsing-remitting MS1 and ▼teriflunomide for the management of relapsing-remitting MS in adults.2 Here, we review...

BACKGROUND Radiotherapy is frequently used in treatment approaches of pelvic malignancies. Nevertheless, it has some known systemic effects on blood cells and the immune system that possibly results in their susceptibility to infection. Probiotics are live microbial food ingredients that provide a health advantage to the consumer. Honey has prebiotic properties. The aim of this clinical trial w...

phamide, and Rituximab Versus FCR Alone in Subjects With Relapsed Chronic Lymphocytic Leukemia] study).8 If the results of this pivotal trial confirm the findings of Byrd et al,7 it will have an important influence on the treatment strategy of patients with CLL. In recent years, 4 drug combination therapies with FCR and alemtuzumab or FCR and mitoxantrone in refractory/relapsed CLL patients wer...

Bacillus pumilus RI06-95 is a marine bacterium isolated in Narragansett, Rhode Island, which has shown probiotic activity against marine pathogens in larval shellfish. We report the genome of B. pumilus RI06-95, which provides insight into the microbe's probiotic ability and may be used in future studies of the probiotic mechanism.

INTRODUCTION Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol. OBJECTIVE To evaluate the effects of probiotics on human serum lipid levels, we conducted a meta-analysis of interventional studies. ...

Acute diarrhoea remains a major public health challenge in developing countries. We examined the role of a probiotic in the prevention of acute diarrhoea to discover if there was an effect directed towards a specific aetiology. A double-blind, randomized, controlled field trial involving 3758 children aged 1-5 years was conducted in an urban slum community in Kolkata, India. Participants were g...

BACKGROUND AND AIMS Probiotic supplementation seems to provide beneficial effects in the prevention and treatment of radiation-induced diarrhea. We performed a systematic review and meta-analysis to estimate the efficacy of probiotic supplementation for prevention and treatment of radiation-induced diarrhea. METHODS Two reviewers independently searched PubMed, EMBASE, Cochrane Library, Google...

Germfree beige-nude ( bg/bg-nu/nu) and beige-heterozygous ( bg/bg-nu/+) mice were colonized with a pure culture of Candida albicans or with a probiotic bacterium (Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus casei, or Bifidobacterium infantis). Probiotic-colonized mice were subsequently challenged orally with C. albicans. The effect of prior colonization with probiotic bacter...

Objective: Standard triple therapy for H. pylori eradication is no longer effective in many countries including Thailand. This study was designed to evaluate the efficacy of adding bismuth and probiotic supplement to standard triple therapy for H. pylori eradication in Thai patients. Method: This prospective single-center study was conducted in Thailand. H pylori infected gastritis patients wer...

The presence of large amounts of probiotic bacteria in a sample may interfere with the detection of undesirable microorganisms. To illustrate this, infant formula with various strains of probiotic bacteria and the corresponding probiotic culture powders and premixes were artificially contaminated with low levels of Salmonella. Recovery of Salmonella was generally very poor when the conventional...