OBJECTIVES Various grafts or combination of graft materials have been used in sinus floor augmentations, and human histological reports on their performance are available, although limited in number. Histological analysis of the regenerated tissues will provide useful information regarding the nature and amount of newly formed bone. Aim of the present study was a histological and histomorphomet...

All treatment involving the use of biomaterials in the body can affect the host in positive or negative ways. The microbiological environment in the oral cavity is affected by the composition and shape of the biomaterials used for oral restorations. This may impair the patients’ oral health and sometimes their general health as well. Many factors determine the composition of the microbiota and ...

Presently, several different graft materials are employed in regenerative or corrective bone surgery. However current misconceptions about these biomaterials, their use and risks may compromise their correct application and development. To unveil these misconceptions, this work briefly reviewed concepts about bone remodeling, grafts classification and manufacturing processes, with a special foc...

The integration of biomaterials with skin is necessary to enable infection-free access to vasculature and body cavities. Also, integrating plastics and metals with skin increases options for the reconstruction of surgical and traumatic defects and enables the permanent implantation of robotic and electronic devices. Until now, attempts to integrate biomaterials with skin permanently have failed...

BACKGROUND Many materials are unsuitable for medical use because of poor biocompatibility. Recently, advances in the high throughput synthesis of biomaterials has significantly increased the number of potential biomaterials, however current biocompatibility analysis methods are slow and require histological analysis. METHODOLOGY/PRINCIPAL FINDINGS Here we develop rapid, non-invasive methods f...

The use of biomaterials, such as hydrogels, as a scaffold to deliver cells and drugs is becoming increasingly common to treat neurological conditions, including stroke. With a limited intrinsic ability to regenerate after injury, innovative tissue engineering strategies have shown the potential of biomaterials in facilitating neural tissue regeneration and functional recovery. Using biomaterial...

Derived from any somatic cell type and possessing unlimited self-renewal and differentiation potential, induced pluripotent stem cells (iPSCs) are poised to revolutionize stem cell biology and regenerative medicine research, bringing unprecedented opportunities for treating debilitating human diseases. To overcome the limitations associated with safety, efficiency, and scalability of traditiona...