Photoacoustic tomography (PAT) is probably the fastest growing biomedical imaging technology owing to its capability of high-resolution sensing of rich optical contrast in vivo at depths beyond the optical transport mean free path (~1 mm in the skin). Existing high-resolution optical imaging technologies, such as confocal microscopy and two-photon microscopy, have fundamentally impacted biomedi...

The ability to obtain comprehensive structural and functional information from intact biological tissue in vivo is highly desirable for many important biomedical applications, including cancer and brain studies. Here, we developed a fully integrated multimodal microscopy that can provide photoacoustic (optical absorption), two-photon (fluorescence), and second harmonic generation (SHG) informat...

Objective (s): SrCO3 nanoparticles could be used as new biomedical sources in magnetic resonance imaging as a promising noninvasive imaging modality for the preoperative staging of breast cancer and monitoring of tumor response to therapy. The present study aimed to synthesize SrCO3 nanostructures using microwave irradiation in the presence of honey as a green capping agent and reductant. Mater...

Metal oxide nanoparticles due to their antioxidant properties have attractedsignificant attention and exhibited good potential for use in cancer theranostics.Owing to the poor absorption in the physiological environment, they are anideal candidate to act as nanocarriers in targeted drug delivery and bioimaging.This feature can be successfully implemented in live monitori...

Microfluidic devices have undergone rapid development in recent years and provide a lab-on-a-chip solution for many biomedical and chemical applications. Optical imaging techniques are essential in microfluidics for observing and extracting information from biological or chemical samples. Traditionally, imaging in microfluidics is achieved by bench-top conventional microscopes or other bulky im...

Recently developed optical-resolution photoacoustic microscopy (OR-PAM), which is based on the detection of optical absorption contrast, is complementary to other optical microscopy modalities such as optical confocal microscopy, optical coherence tomography, and multiphoton microscopy. A hybrid optical-mechanical scanning configuration increases the imaging speed of OR-PAM significantly, facil...

The editors introduce the Biomedical Optics Express feature issue, “Advances in Optical Coherence Tomography, Photoacoustic Imaging, and Microscopy,” which combines three technical areas from the 2010 Optical Society of America (OSA), Biomedical Optics (BIOMED) Topical Meeting held on 11–14 April in Miami, Florida, and includes contributions from conference attendees. © 2010 Optical Society of ...

Optical imaging in a highly scattering medium is effective only at very shallow depths which limits its use as a diagnostic tool in biomedical imaging, particularly for tumor detection. By combining optical and acoustic modalities, high-contrast, tumor state-relevant optical information at higher spatial resolutions can be achieved. Hybrid imaging modalities such as acousto-optic and photoacous...