Recent reports by Bielschowsky (1), Harris (6), Engel and Copeland (5), Strombeck and Ekman (10), and Morris et al. (7), indicate that the genetic constitution of the rat plays a more dominant role than diet in the initiation of 2-acetylaminofluorene-induced neoplasms. While liver tumors occur in a majority of the rats and the frequency is altered somewhat by the protein content of the diet, th...

We performed a dosimetric comparison of sequential IMRT (sIMRT) and simul-taneously integrated boost (SIB) IMRT to boost PET-avid lymph nodes while concurrently treating pelvic targets to determine the potential of SIB IMRT to reduce overall treatment duration in locally advanced cervical cancer. Ten patients receiving definitive radiation therapy were identified retrospectively. RTOG consensus...

NMNAT2 is an NAD(+)-synthesizing enzyme with an essential axon maintenance role in primary culture neurons. We have generated an Nmnat2 gene trap mouse to examine the role of NMNAT2 in vivo. Homozygotes die perinatally with a severe peripheral nerve/axon defect and truncated axons in the optic nerve and other CNS regions. The cause appears to be limited axon extension, rather than dying-back de...

Delivered dose can be calculated by transferring the planned treatment beams onto the daily CBCT. Bladder and rectum volumetric doses were calculated and cor-related to the daily bladder and rectum fullness. Patients for this study underwent hypofractionated prostate IMRT to 70 Gy in 28 fractions. Daily CBCT was utilized for image guidance. A clinically acceptable plan was created using a CTV-t...

OBJECTIVES To evaluate if the Human epidermal growth factor receptor 2 (HER-2) expression levels may be used as potential prognostic marker in high grade T1 blad- der cancer (T1G3) METHODS: Specimens from transurethral resection of bladder tumour (TURBT) of 103 patients with high-grade T1 bladder cancer were collected. This pathologic database was reviewed. Four-year follow-up data were matched...

tumors of t h e male u ret h ra are r a re, co m prising <1% of urolo g ic malignancies. this is a re po rt of a 44-ye a r-old man pre s ented with a 4 -month history of gross initi a l h e maturia and d y s u ri a . af t e r exami n ing the pa t ien t , we found a firm mass ex t ending 1 c m within the p roxim a l bulb a r uret h ra and a pathologic report of moderately differen t iated sq u a...