OBJECTIVE To examine the frequency and determinants of re-infarction after thrombolytic treatment of ST-elevation myocardial infarction (STEMI). DESIGN Observational study of national registry. SETTING Emergency ambulance services and admitting hospitals in England and Wales. PATIENTS 35 356 patients with STEMI given thrombolytic treatment in 2005-6. MAIN OUTCOME MEASURES Re-infarction ...

BACKGROUND Practice-based general dental practitioners routinely provide "scale and polish" or "oral prophylaxis" to patients attending their practices. Despite its routine provision, there is no evidence to support the clinical effectiveness of single-visit scale and polish, nor the frequency at which it should be provided. A recent systematic review recommended that future trials investigatin...

Acquired inhibitors to coagulation factors other than factor VIII are extremely rare. We describe a case of a 59-year-old woman with abnormal bleeding, diagnosed with concurrent inhibitor antibodies to factor VIII and IX by Bethesda testing. We demonstrate that anti-FVIII antibodies of a very high titre are capable of disturbing the aPTT-based Bethesda assay, resulting in falsely-positive antib...

Based on data from a survey of biological scientists at 125 American universities, this article explores how the commercialization of the university affects the problems academic scientists pursue and argues that this reorientation of scientific agendas results in a shift from science in the public interest to science for private goods. Drawing on perspectives from Bourdieu on how actors employ...

INTRODUCTION AND GOALS Adenotonsillar surgery represents a major haemostatic challenge in paediatric patients with mild inherited platelet dysfunction. While there are recommendations for perioperative haemostatic management, there are no reports of the outcomes with the different recommendations in these children when undergoing adenotonsillectomy. Our objective was to evaluate the management ...

Although traditionally fresh frozen plasma (FFP) has been the product of choice for reversing a significant coagulopathy, the modern blood bank will have several different plasma preparations which should all be equally efficacious in reversing a significant coagulopathy or arresting coagulopathic bleeding. Emerging evidence suggests that for a stable patient, transfusing plasma for an INR≤1.5 ...

Recently, perfectionism has become a focus of attention in applied psychology. In athletic populations, both adaptive and maladaptive perfectionism have been found to exist (Terry-Short et al., 1995) but little research has been done on the relationships between perfectionistic tendencies and mood states in athletes. By furthering our understanding of potential relationships between perfectioni...

Suzuki/2007 (18) Japan NVAF n=667 Target INR value was set at 1.6–2.6 Incidence of major bleeding was 2.38%, which is higher than in Western patients INR ≥2.27 was an independent risk factor for major bleeding NVAF, non-valvular atrial fibrillation; INR, international normalised ratio; d, days. Current antithrombotic treatment in East Asia: Some perspectives on anticoagulation and antiplatelet ...

Self-medication is a widespread behavior worldwide. It is defined as the practice of self-diagnosis and drug prescription without proper professional consultation. Aim: To determine the prevalence and predictors of self-medication for oral health problems among adults living in Riyadh city. Methods: A cross-sectional study based on a structured close-ended questionnaire was distributed among ad...

CONTEXT Bleeding complications with percutaneous coronary intervention (PCI) are associated with adverse patient outcomes. The association between the use of bleeding avoidance strategies and post-PCI bleeding as a function of a patient's preprocedural risk of bleeding is unknown. OBJECTIVE To describe the use of 2 bleeding avoidance strategies, vascular closure devices and bivalirudin, and a...