Brain-targeted drug delivery is a field of research that seeks to develop new methods for delivering drugs the brain. This done by overcoming blood-brain barrier (BBB), network cells tightly regulate flow substances between blood and Most time lipophilic are easily cross brain but few them less soluble in lipid therefore they don’t barrier. After review we concluded can improve solubility using...

endothelial cells present in brain are unique and differ from other peripheral tissues in a number of ways, which ensures specific brain endothelial barrier properties. endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation. various micrornas (mirna) have been discovered in different cellular components of the blood bran barrier (bbb). mirnas a...

The large surface area and the short diffusion distance from capillaries of the blood brain barrier (BBB) to the neurons facilitate the drugs and nutrients access to the brain. Penetration of chemicals to the BBB occurs using a combination of intra and intercellular passages. Tight junctions regulate the intracellular passage of molecules according to their physicochemical properties (e.g. lipo...

In autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS). The BBB's unique anatomic structure and the tightly regulated interplay of its cellular and acellular components a...

The graphical tools (see Section 4) showed that the logarithmic transformation applied to both the response (concentration ratio) and the explanatory variable sacrifice time makes the relationship between the two variables approximately linear. In this section we will examine the relationship between the logarithm of concentration ratio (LNRATIO) and the eight explanatory variables with the fol...

Introduction: Recent studies suggest that dietary virgin olive oil (VOO) reduces hypoxia-re oxygenation injury in rat brain. We have attempted to determine the effect of dietary virgin olive oil on brain lipidomics and its relationship with brain edema in a rat stroke model. Methods: Five groups, each consisting of 6 male Wistar rats, were studied. The first and second groups (control and s...