In order to find out the effect of organic arsenic compounds in form salvarsan and its derivatives on blood clotting author set a series vitro vivo experiments by methods Brkеrʹa Schultz'a. These convinced that such as already minimal amounts cause retardation.

The synthesis of racemic 1,2-dioleoyl and 1 -oleoyl-2-stearoyl glycerol-3-phosphoryl serine was achieved by the phosphorylation of unsaturated diglycerides with phosphorus oxychloride, and combination with the phthalimidomethyl ester of carbo-t-butoxy-DL-serine. The synthetic phosphatidyl serines were tested in blood clotting systems in vitro. They have activity qualitatively similar to that of...

Most steps of the blood clotting cascade require the assembly of a serine protease with its specific regulatory protein on a suitable phospholipid bilayer. Unfortunately, the molecular details of how blood clotting proteins bind to membrane surfaces remain poorly understood, owing to a dearth of techniques for studying protein-membrane interactions at high resolution. Our laboratories are tackl...

Crystal Surfaces Crystallographic orientation, and therefore the arrangement coordination number of surface atoms, defines energy wettability, subsequently controlling cellular response to blood-contacting biomaterials. Depending on crystallographic orientation TiO2 (rutile) surfaces, fibrinogen adsorbs typically in a trinodular and/or globular conformation, determining platelet adhesion activa...

• Recent studies from this laboratory have shown that the clotting time of blood' and the morphology of blood clots' can be altered markedly by flow of blood during the period of clotting. The rheology of clots has been studied by Hartert, de Nicola, and Marchal et al. by means of thrombelastography, while Scott Blair and Copley and Scott Blair employed a gelometer. However, no observations hav...

The effectiveness and mechanism of a low temperature air plasma torch in clotting blood are explored. Both blood droplets and smeared blood samples were used in the tests. The treated droplet samples reveal how blood clotting depends on the distance at which the torch operated, and for how long the droplets have been exposed to the torch. Microscopy and cell count of smeared blood samples shed ...

Haemophilia is an inherited disorder of the body's blood clotting mechanism. Past treatments have led to the transmission of blood-borne viruses, primarily HIV and hepatitis C. Current clotting factor concentrates and treatment regimes offer patients a good quality of life. Specialist haemophilia nurses play a pivotal role in the organisation and delivery of care to this patient group.

During normal pregnancy, the concentrations of many of the clotting factors rise, thereby increasing the potential to generate fibrin. There is also evidence of increased thrombin activity during normal pregnancy which sharply increases during placental separation. Antithrombin III, the main inhibitor of thrombin and activated factor X, shows no compensatory rise during pregnancy but increases ...