The blood and lymphatic vasculatures are structurally and functionally coupled in controlling tissue perfusion, extracellular interstitial fluids, and immune surveillance. Little is known, however, about the molecular mechanisms that underlie the regulation of bloodlymphatic vessel connections and lymphatic perfusion. Here we show in the adult zebrafish and glass catfish (Kryptopterus bicirrhis...

The aim of the present study was to evaluate and cor-relate islet to brown and white adipose tissue (WAT) blood perfusion in one obese rat and one nonobese rat with type 2 diabetes (obese Zucker [OZ] and GK rats, respectively). We measured blood perfusion with a microsphere technique in anesthetized animals and subsequently estimated the blood flow to seven different WAT depots and brown adipos...

Metabolic studies using the in vitro non-recirculating blood-perfused isolated heart model require large volumes of blood. The present study was designed to determine whether heterologous pig blood collected from a slaughterhouse can be used as perfusate for isolated pig hearts perfused under aerobic and constant reduced flow conditions. Eight isolated working pig hearts perfused for 90 min at ...

The main function of ocular blood flow is to supply sufficient oxygen and nutrients to the eye. Local blood vessels resistance regulates overall blood distribution to the eye and can vary rapidly over time depending on ocular need. Under normal conditions, the relation between blood flow and perfusion pressure in the eye is autoregulated. Basically, autoregulation is a capacity to maintain a re...

Cerebral perfusion pressure was reduced by graded constricting of both carotid arteries in the anesthetized dogs, of which vertebral arteries were ligated bilaterally. Cerebral blood flow and cerebral metabolic rate of oxygen remained unchanged until cerebral perfusion pressure was lowered to about 50 mm.Hg, indicating that cerebral autoregulation was preserved normally in these animals. Despit...

The development of a data management solution that is used for the collection, storage, and retrieval of numerical data in a clinical setting to infer perfusion through a non-invasive thermal method is the impetus for this study. The concept of a self-heated thermistor bead located between a kidney and adjacent tissue is analyzed to determine the efficacy of the procedure to infer perfusion aft...

The brain and other organs locally synthesize steroids. Local synthesis is suggested when steroid levels are higher in tissue than in the circulation. However, measurement of both circulating and tissue steroid levels are subject to methodological considerations. For example, plasma samples are commonly used to estimate circulating steroid levels in whole blood, but steroid levels in plasma and...

Measurements of cerebral perfusion have become an important part of diagnostic imaging and therapy monitoring in a variety of brain diseases. Magnetic resonance perfusion imaging provides high-resolution images of various perfusion parameters in addition to the important morphological information acquired during the same imaging session. In conjunction with magnetic resonance imaging (MRI) diff...

BACKGROUND AND PURPOSE Several recent studies analyzing perfusion changes in acute intracerebral hemorrhage fed the debate whether there is secondary ischemic tissue damage in the vicinity of intracerebral hemorrhage. We used perfusion CT to address this question. METHODS We examined 36 patients between 2001 and 2002 with acute intracerebral hemorrhage (within 24 hours after symptom onset). A...

BACKGROUND Systemic inflammation can be associated with a redistribution of organ blood flow and a decrease in gastrointestinal perfusion. Regional sympathetic blockade by means of thoracic epidural anesthesia (TEA) has been shown to improve intestinal microcirculation during systemic inflammation. This study tests the hypothesis that during systemic inflammation, TEA attenuates the impairment ...