The long-term stability and qualitative characteristics of periodontium regenerated by FGF-2 treatment were compared with normal physiological healing tissue controls in a Beagle dog 2-wall periodontal defect model 13 months after treatment by assessing tissue histology and three-dimensional microstructure using micro-computed tomography (μCT). After FGF-2 (0.3%) or vehicle treatment at the def...

OBJECTIVE The aim of this study was to investigate the correlation between interdental and interradicular bone loss and clinical parameters in patients with chronic periodontitis. MATERIALS AND METHODS One hundred-twenty intraoral periapical radiographs of first molars were obtained from patients with chronic periodontitis and were digitalized to record height and width of the bone defect in ...

The objective of this study was to investigate the in vivo biomechanical performance of bone defects implanted with novel bilayer hydroxyapatite (HAp) scaffolds that mimic the cortical and cancellous organization of bone. The scaffolds maintained architectural continuity in a rabbit radius segmental defect model and were compared to an untreated defect group (negative control) and autologous bo...

BACKGROUND: Dental disease, trauma and maxillofacial surgeries can cause alveolar bone defects. Among different kinds of treatment, autogenous bone grafts is accepted as a golden standard. On the other hand, because of limitation of treatment with autogenous bone grafts, osteogenic cells derived from stem cells are suggested. OBJECTIVES: The aim of this study was to compare the mean density of ...

Platelet-rich plasma (PRP), a platelet concentrate made of autogenous blood, has been used in recent years to improve bone defect healing particularly in maxillofacial reconstructions. The aim of the present study was to assess the effect of PRP on new bone formation in a critical diaphyseal long bone defect. A critical size defect (2.5 cm) in the tibial diaphysis of 16 sheep was supplied eithe...

Abstract The limited options for bone repair have led to an extensive research of the field and development alloplastic xenogeneic grafts. purpose this study was evaluate with two substitutes: deproteinized bovine (DBB) biphasic calcium phosphate ceramic (BCP) in critical-size defect. A total 8-mm defects were made parietal bones rabbits (n=12). animals divided into three experimental groups: s...

Treatment of proximal tibial defects is important to the survival of tibial prosthesis after total knee replacement. The objective of this finite element study was to determine a better understanding of the stresses produced by different treatment options for moderate uncontained type-2 defects. Methods analysed were the use of metal wedges, metal blocks, cement wedges, and cement blocks for th...

OBJECTIVE The aim of this study was to evaluate the osteoconductive potential of BoneCeramic™ on bone healing in rat calvaria 5-mm defects. MATERIAL AND METHODS A 5-mm calvaria bone defect was induced in three groups and the defect was not filled with biomaterial [Clot Group (CG)], autogenous bone (AG), or Bone Ceramic Group (BCG). Animals were euthanized after 14 or 28 days and the bone tiss...

Multiple methods and materials are available for bone defect reconstruction. Bone graft substitute is one of the materials used for reconstruction of bone defect and have been widely used recently. This report describes some cases about complications related to GeneX® which is introduced as mixture of calcium sulfate and β-tricalcium phosphate at manufacturer's official web site. It informed of...