X-ray-based diagnostic techniques, which are by far the most widely used for diagnosing bone disorders and diseases, are largely blind to the protein component of bone. Bone proteins are important because they determine certain mechanical properties of bone and changes in the proteins have been associated with a number of bone diseases. Spatially Offset Raman Spectroscopy (SORS) is a chemically...

To date, nearly 500 unique rare bone diseases have been described,which in the aggregate affect 1 in 5000 live births and comprise 5% of all birth defects. Currently, the overwhelming majority of these disorders have no cure. Studying rare bone diseases has helped elucidate biological pathways and reveal valuable therapeutic targets that also benefit patients with common bone diseases. In an ef...

Bone remodelling is a complex mechanism regulated by osteoclasts and osteoblasts perturbation of this process leads to the onset diseases, which may be characterised altered bone erosion or formation. In review, we will describe some formation-related disorders as sclerosteosis, van Buchem disease, hypophosphatasia Camurati–Engelmann disease. past decades, research focused on these rare offered...

changes (BMD) and osteoporosis .Helico bacter pylori which is a known cause of gastritis and peptic ulcer Osteopprosis is one major cause of bone fracture and subsequent morbidity and mortality in the elderly population. Several clinical and demographic parameters including aging, menopause, parity , inflammatory disease, hormonal, gastrointestinal, renal and metabolic disorders like vitamin D ...

it appears that until bone graft has not achieved 100% success, intraradicular diseases remain controversial and therefore, different treatment plans are suggested for them. treating intraradicular diseases depend on many factors: maxillary molars are more prone to bone loss and have worse prognosis. to assess prognosis more carefully these factors should be considered: 1) bone loss: its apical...

Bone-related diseases share the process of immune response that targets bone tissue and bone marrow and then induce adverse effects on structure and function. In recent years, reciprocal relationship between immune cells and bone systems has been uncovered gradually. Regulatory T (Treg) and T helper 17 (Th17) cells are newly identified subsets of CD4+ T cells, and the balance between them is pa...

in this session, we will discuss 7 cases in pediatric musculoskeletal field. these cases will include different aspects of bone and msk disorders in pediatrics such as bone tumors (benign and malignant), bone involvement in metabolic and hematologic disorders, infectious diseases and soft tissue vascular lesions. during this session, we will ask some volunteered radiology residents to explain t...