In striving to refine the clinical utility of different markers of bone metabolism, we should take into account numerous confounders, many of which are well known, such as sampling time, fasting status, and bone density. One further confounder may be ongoing fracture healing and/or post-fracture immobilization, which at least theoretically should impose an increased bone formation and resorptio...

Bone formation during fracture repair inevitably initiates within or around extravascular deposits of a fibrin-rich matrix. In addition to a central role in hemostasis, fibrin is thought to enhance bone repair by supporting inflammatory and mesenchymal progenitor egress into the zone of injury. However, given that a failure of efficient fibrin clearance can impede normal wound repair, the preci...

Bone fracture is a health concern for those with aged bone and brittle bone diseases. Mouse bone is widely used as a model of human bone, especially to investigate preclinical treatment strategies. However, little is known about the mechanisms of mouse bone fracture and its similarities and differences from fracture in human bone. In this work we present a methodology to investigate the fractur...

Increased incidence of stress fracture has been reported for amenorrheic runners, while some studies have reported decreased spinal bone mass in amenorrheic runners. Based on results from these studies, one tends to associate decreased spinal bone mass with an increased risk of stress fracture. The present study compared regional bone mass and external loads during running between six female ru...

Osteoporosis has been previously defined in 1993 as a disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk. This definition has been revised in 2001 as a skeletal disorder characterized by compromised bone strength with an increased risk of fracture. The reason for the revision is...

BACKGROUND Fracture healing is orchestrated by a specific set of events that culminates in the repair of bone and reachievement of its biomechanical properties. The aim of our work was to study the sequence of gene expression events involved in inflammation and bone remodeling occurring in the early phases of callus formation in osteoporotic patients. METHODOLOGY/PRINCIPAL FINDINGS Fifty-six ...

his paper is intended as an overview of current bone grafting applications, with special attention given to fracture management, and as such assumes a certain knowledge by the reader of anatomy and medical terminology. Fracture management is one of the oldest medical concerns and was the precursor of many modern orthopedic procedures. Improper fracture management can affect one's livelihood and...

BACKGROUND A number of different bone geometries have been reported to be correlated with osteoporosis, bone mineral density and fractures. Those correlations are used for diagnosis, treatment and prediction of fracture risk in osteoporosis cases. However there have been no studies of significant bone parameters predicting osteoporosis and hip fracture in Thailand OBJECTIVE To evaluate the co...

The need to initiate treatment for a postmenopausal woman with a low bone mass should be based on that individual's fracture risk over a fnite period of time. Fracture assessment tools, such as the recently introduced FRAX(TM) model, allows the clinician to estimate an individual's absolute fracture risk over the next decade of their life. Such estimates are particularly useful for younger post...